EDC IMPACT: Is exposure during pregnancy to acetaminophen/paracetamol disrupting female reproductive development?

Concern has been raised over chemical-induced disruption of ovary development during fetal life resulting in long-lasting consequences only manifesting themselves much later during adulthood. A growing body of evidence suggests that prenatal exposure to the mild analgesic acetaminophen/paracetamo...

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Main Authors: Frederic Schrøder Arendrup, Severine Mazaud-Guittot, Bernard Jégou, David Møbjerg Kristensen
Format: Article
Language:English
Published: Bioscientifica 2018-01-01
Series:Endocrine Connections
Subjects:
Online Access:http://www.endocrineconnections.com/content/7/1/149.full
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spelling doaj-3acace0efc2e44c48b984db2991de5332020-11-25T02:15:10ZengBioscientificaEndocrine Connections2049-36142049-36142018-01-017114915810.1530/EC-17-0298EDC IMPACT: Is exposure during pregnancy to acetaminophen/paracetamol disrupting female reproductive development?Frederic Schrøder Arendrup0Severine Mazaud-Guittot1Bernard Jégou2David Møbjerg Kristensen3Department of Neurology, Danish Headache Center, Rigshospitalet, University of Copenhagen, DenmarkInserm (Institut National de la Santé et de la Recherche Médicale), Irset – Inserm, UMR 1085, Rennes, FranceInserm (Institut National de la Santé et de la Recherche Médicale), Irset – Inserm, UMR 1085, Rennes, France; EHESP-School of Public Health, Rennes, FranceDepartment of Neurology, Danish Headache Center, Rigshospitalet, University of Copenhagen, Denmark; Inserm (Institut National de la Santé et de la Recherche Médicale), Irset – Inserm, UMR 1085, Rennes, FranceConcern has been raised over chemical-induced disruption of ovary development during fetal life resulting in long-lasting consequences only manifesting themselves much later during adulthood. A growing body of evidence suggests that prenatal exposure to the mild analgesic acetaminophen/paracetamol can cause such a scenario. Therefore, in this review, we discuss three recent reports that collectively indicate that prenatal exposure in a period of 13.5 days post coitum in both rats and mouse can result in reduced female reproductive health. The combined data show that the exposure results in the reduction of primordial follicles, irregular menstrual cycle, premature absence of corpus luteum, as well as reduced fertility, resembling premature ovarian insufficiency syndrome in humans that is linked to premature menopause. This could especially affect the Western parts of the world, where the age for childbirth is continuously being increased and acetaminophen is recommended during pregnancy for pain and fever. We therefore highlight an urgent need for more studies to verify these data including both experimental and epidemiological approaches.http://www.endocrineconnections.com/content/7/1/149.fullfertilityfolliclesprimordial germ cellsacetaminophen/ paracetamoltylenoldevelopment
collection DOAJ
language English
format Article
sources DOAJ
author Frederic Schrøder Arendrup
Severine Mazaud-Guittot
Bernard Jégou
David Møbjerg Kristensen
spellingShingle Frederic Schrøder Arendrup
Severine Mazaud-Guittot
Bernard Jégou
David Møbjerg Kristensen
EDC IMPACT: Is exposure during pregnancy to acetaminophen/paracetamol disrupting female reproductive development?
Endocrine Connections
fertility
follicles
primordial germ cells
acetaminophen/ paracetamol
tylenol
development
author_facet Frederic Schrøder Arendrup
Severine Mazaud-Guittot
Bernard Jégou
David Møbjerg Kristensen
author_sort Frederic Schrøder Arendrup
title EDC IMPACT: Is exposure during pregnancy to acetaminophen/paracetamol disrupting female reproductive development?
title_short EDC IMPACT: Is exposure during pregnancy to acetaminophen/paracetamol disrupting female reproductive development?
title_full EDC IMPACT: Is exposure during pregnancy to acetaminophen/paracetamol disrupting female reproductive development?
title_fullStr EDC IMPACT: Is exposure during pregnancy to acetaminophen/paracetamol disrupting female reproductive development?
title_full_unstemmed EDC IMPACT: Is exposure during pregnancy to acetaminophen/paracetamol disrupting female reproductive development?
title_sort edc impact: is exposure during pregnancy to acetaminophen/paracetamol disrupting female reproductive development?
publisher Bioscientifica
series Endocrine Connections
issn 2049-3614
2049-3614
publishDate 2018-01-01
description Concern has been raised over chemical-induced disruption of ovary development during fetal life resulting in long-lasting consequences only manifesting themselves much later during adulthood. A growing body of evidence suggests that prenatal exposure to the mild analgesic acetaminophen/paracetamol can cause such a scenario. Therefore, in this review, we discuss three recent reports that collectively indicate that prenatal exposure in a period of 13.5 days post coitum in both rats and mouse can result in reduced female reproductive health. The combined data show that the exposure results in the reduction of primordial follicles, irregular menstrual cycle, premature absence of corpus luteum, as well as reduced fertility, resembling premature ovarian insufficiency syndrome in humans that is linked to premature menopause. This could especially affect the Western parts of the world, where the age for childbirth is continuously being increased and acetaminophen is recommended during pregnancy for pain and fever. We therefore highlight an urgent need for more studies to verify these data including both experimental and epidemiological approaches.
topic fertility
follicles
primordial germ cells
acetaminophen/ paracetamol
tylenol
development
url http://www.endocrineconnections.com/content/7/1/149.full
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