Synovial Mesenchymal Stem Cell-Derived EV-Packaged miR-31 Downregulates Histone Demethylase KDM2A to Prevent Knee Osteoarthritis

Synovial Mesenchymal Stem Cell-Derived EV-Packaged miR-31 Downregulates Histone Demethylase KDM2A to Prevent Knee Osteoarthritis

Extracellular vesicles (EVs) derived from mesenchymal stem cells (MSCs) have emerged as important mediators of intercellular communication in response to cartilage damage. In this study, we sought to characterize the inhibitory role of microRNA (miR)-31 encapsulated in synovial MSC (SMSC)-derived EV...

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Bibliographic Details
Main Authors: Kunpeng Wang, Feng Li, Yuan Yuan, Liang Shan, Yong Cui, Jing Qu, Feng Lian
Format: Article
Language:English
Published: Elsevier 2020-12-01
Series:Molecular Therapy: Nucleic Acids
Subjects:
mesenchymal stem cell-derived extracellular vesicles
microRNA-31
KDM2A
E2F1
PTTG1
knee osteoarthritis
Online Access:http://www.sciencedirect.com/science/article/pii/S2162253120302857

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