Human T Cell Differentiation Negatively Regulates Telomerase Expression Resulting in Reduced Activation-Induced Proliferation and Survival

Human T Cell Differentiation Negatively Regulates Telomerase Expression Resulting in Reduced Activation-Induced Proliferation and Survival

Maintenance of telomeres is essential for preserving T cell proliferative responses yet the precise role of telomerase in human T cell differentiation, function, and aging is not fully understood. Here we analyzed human telomerase reverse transcriptase (hTERT) expression and telomerase activity in s...

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Bibliographic Details
Main Authors: Michael S. Patrick, Nai-Lin Cheng, Jaekwan Kim, Jie An, Fangyuan Dong, Qian Yang, Iris Zou, Nan-ping Weng
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-08-01
Series:Frontiers in Immunology
Subjects:
T lymphocytes
T cell subsets
telomerase
hTERT
alternative splicing
differentiation
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2019.01993/full

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