GPR40/FFAR1 deficient mice increase noradrenaline levels in the brain and exhibit abnormal behavior

GPR40/FFAR1 deficient mice increase noradrenaline levels in the brain and exhibit abnormal behavior

The free fatty acid receptor 1 (GPR40/FFAR1) is a G protein-coupled receptor, which is activated by long chain fatty acids. We have previously demonstrated that activation of brain GPR40/FFAR1 exerts an antinociceptive effect that is mediated by the modulation of the descending pain control system....

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Bibliographic Details
Main Authors: Fuka Aizawa, Takashi Nishinaka, Takuya Yamashita, Kazuo Nakamoto, Takashi Kurihara, Akira Hirasawa, Fumiyo Kasuya, Atsuro Miyata, Shogo Tokuyama
Format: Article
Language:English
Published: Elsevier 2016-12-01
Series:Journal of Pharmacological Sciences
Subjects:
GPR40/FFAR1
Free fatty acid
Anxiety
Sucrose preference
Noradrenaline
Online Access:http://www.sciencedirect.com/science/article/pii/S134786131630158X

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