Comprehensive Analysis of CDR3 Sequences in Gluten-Specific T-Cell Receptors Reveals a Dominant R-Motif and Several New Minor Motifs

Comprehensive Analysis of CDR3 Sequences in Gluten-Specific T-Cell Receptors Reveals a Dominant R-Motif and Several New Minor Motifs

Gluten-specific CD4+ T cells are drivers of celiac disease (CeD). Previous studies of gluten-specific T-cell receptor (TCR) repertoires have found public TCRs shared across multiple individuals, biased usage of particular V-genes and conserved CDR3 motifs. The CDR3 motifs within the gluten-specific...

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Bibliographic Details
Main Authors: Shiva Dahal-Koirala, Louise Fremgaard Risnes, Ralf Stefan Neumann, Asbjørn Christophersen, Knut E. A. Lundin, Geir Kjetil Sandve, Shuo-Wang Qiao, Ludvig M. Sollid
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-04-01
Series:Frontiers in Immunology
Subjects:
celiac disease
T-cell receptors
gluten-specific T-cell receptors
CDR3 motifs
public T-cell receptors
R-motif
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2021.639672/full

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