New Cembranoids and a Biscembranoid Peroxide from the Soft Coral Sarcophyton cherbonnieri

Six new cembranoids, cherbonolides A−E (1–5) and bischerbolide peroxide (6), along with one known cembranoid, isosarcophine (7), were isolated from the Formosan soft coral Sarcophyton cherbonnieri. The structures of these compounds were elucidated by detailed spectroscopic analysis and chemical meth...

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Main Authors:	Chia-Chi Peng, Chiung-Yao Huang, Atallah F. Ahmed, Tsong-Long Hwang, Chang-Feng Dai, Jyh-Horng Sheu
Format:	Article
Language:	English
Published:	MDPI AG 2018-08-01
Series:	Marine Drugs
Subjects:	Sarcophyton cherbonnieri cembranoid biscembranoid peroxide anti-inflammatory activity elastase release inhibition
Online Access:	http://www.mdpi.com/1660-3397/16/8/276

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spelling	doaj-3a9a7f7aa4a14db3a9d4b97dd520ce062020-11-24T21:17:19ZengMDPI AGMarine Drugs1660-33972018-08-0116827610.3390/md16080276md16080276New Cembranoids and a Biscembranoid Peroxide from the Soft Coral Sarcophyton cherbonnieriChia-Chi Peng0Chiung-Yao Huang1Atallah F. Ahmed2Tsong-Long Hwang3Chang-Feng Dai4Jyh-Horng Sheu5Department of Marine Biotechnology and Resources, National Sun Yat-sen University, Kaohsiung 804, TaiwanDepartment of Marine Biotechnology and Resources, National Sun Yat-sen University, Kaohsiung 804, TaiwanDepartment of Pharmacognosy, College of Pharmacy, King Saud University, Riyadh 11451, Saudi ArabiaGraduate Institute of Natural Products, College of Medicine, Chang Gung University, Taoyuan 333, TaiwanInstitute of Oceanography, National Taiwan University, Taipei 112, TaiwanDepartment of Marine Biotechnology and Resources, National Sun Yat-sen University, Kaohsiung 804, TaiwanSix new cembranoids, cherbonolides A−E (1–5) and bischerbolide peroxide (6), along with one known cembranoid, isosarcophine (7), were isolated from the Formosan soft coral Sarcophyton cherbonnieri. The structures of these compounds were elucidated by detailed spectroscopic analysis and chemical methods. Compound 6 was discovered to be the first example of a molecular skeleton formed from two cembranoids connected by a peroxide group. Compounds 1–7 were shown to have the ability of inhibiting the production of superoxide anions and elastase release in N-formyl-methionyl-leucyl-phenylalanine/cytochalasin B (fMLF/CB)-induced human neutrophils.http://www.mdpi.com/1660-3397/16/8/276Sarcophyton cherbonniericembranoidbiscembranoid peroxideanti-inflammatory activityelastase release inhibition
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Chia-Chi Peng Chiung-Yao Huang Atallah F. Ahmed Tsong-Long Hwang Chang-Feng Dai Jyh-Horng Sheu
spellingShingle	Chia-Chi Peng Chiung-Yao Huang Atallah F. Ahmed Tsong-Long Hwang Chang-Feng Dai Jyh-Horng Sheu New Cembranoids and a Biscembranoid Peroxide from the Soft Coral Sarcophyton cherbonnieri Marine Drugs Sarcophyton cherbonnieri cembranoid biscembranoid peroxide anti-inflammatory activity elastase release inhibition
author_facet	Chia-Chi Peng Chiung-Yao Huang Atallah F. Ahmed Tsong-Long Hwang Chang-Feng Dai Jyh-Horng Sheu
author_sort	Chia-Chi Peng
title	New Cembranoids and a Biscembranoid Peroxide from the Soft Coral Sarcophyton cherbonnieri
title_short	New Cembranoids and a Biscembranoid Peroxide from the Soft Coral Sarcophyton cherbonnieri
title_full	New Cembranoids and a Biscembranoid Peroxide from the Soft Coral Sarcophyton cherbonnieri
title_fullStr	New Cembranoids and a Biscembranoid Peroxide from the Soft Coral Sarcophyton cherbonnieri
title_full_unstemmed	New Cembranoids and a Biscembranoid Peroxide from the Soft Coral Sarcophyton cherbonnieri
title_sort	new cembranoids and a biscembranoid peroxide from the soft coral sarcophyton cherbonnieri
publisher	MDPI AG
series	Marine Drugs
issn	1660-3397
publishDate	2018-08-01
description	Six new cembranoids, cherbonolides A−E (1–5) and bischerbolide peroxide (6), along with one known cembranoid, isosarcophine (7), were isolated from the Formosan soft coral Sarcophyton cherbonnieri. The structures of these compounds were elucidated by detailed spectroscopic analysis and chemical methods. Compound 6 was discovered to be the first example of a molecular skeleton formed from two cembranoids connected by a peroxide group. Compounds 1–7 were shown to have the ability of inhibiting the production of superoxide anions and elastase release in N-formyl-methionyl-leucyl-phenylalanine/cytochalasin B (fMLF/CB)-induced human neutrophils.
topic	Sarcophyton cherbonnieri cembranoid biscembranoid peroxide anti-inflammatory activity elastase release inhibition
url	http://www.mdpi.com/1660-3397/16/8/276
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New Cembranoids and a Biscembranoid Peroxide from the Soft Coral Sarcophyton cherbonnieri

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