Análise térmica aplicada a fármacos e formulações farmacêuticas na indústria farmacêutica

• Main Authors: Marcelo Antonio de Oliveira, Maria Irene Yoshida, Elionai Cassiana de Lima Gomes
• Format: Article
• Language: English
• Published: Sociedade Brasileira de Química 2011-01-01
• Series: Química Nova
• Subjects: thermal analysis; pharmaceutical industry; characterization
• Online Access: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-40422011000700022&lng=en&tlng=en

Several matters of the pharmaceutical demonstrate the great importance of thermal analysis application, especially TG and DSC for the pharmaceutical industry future, namely: characterization of the drugs with the thermal events definition, in studies of drug purity, in the polymorphs identification, in compatibility studies of solid dosage pharmaceutical formulations, in drugs and pharmaceutical formulations thermal stability, and in determination of shelf life for isothermal degradation kinetics by extrapolation using the Arrhenius equation. Thus, the test results obtained from thermal analysis are directly related to the quality of a pharmaceutical product, whether the stability or bioavailability of the pharmaceutical product.