High-Risk Multiple Myeloma: Integrated Clinical and Omics Approach Dissects the Neoplastic Clone and the Tumor Microenvironment

High-Risk Multiple Myeloma: Integrated Clinical and Omics Approach Dissects the Neoplastic Clone and the Tumor Microenvironment

Multiple myeloma (MM) is a genetically heterogeneous disease that includes a subgroup of 10−15% of patients facing dismal survival despite the most intensive treatment. Despite improvements in biological knowledge, MM is still an incurable neoplasia, and therapeutic options able to overcom...

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Main Authors: Antonio Giovanni Solimando, Matteo Claudio Da Vià, Sebastiano Cicco, Patrizia Leone, Giuseppe Di Lernia, Donato Giannico, Vanessa Desantis, Maria Antonia Frassanito, Arcangelo Morizio, Julia Delgado Tascon, Assunta Melaccio, Ilaria Saltarella, Giuseppe Ranieri, Roberto Ria, Leo Rasche, K. Martin Kortüm, Andreas Beilhack, Vito Racanelli, Angelo Vacca, Hermann Einsele
Format: Article
Language:English
Published: MDPI AG 2019-07-01
Series:Journal of Clinical Medicine
Subjects:
multiple myeloma
angiogenesis
extramedullary disease
drug resistance
bone marrow microenvironment
Online Access:https://www.mdpi.com/2077-0383/8/7/997

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