Multi-enhancer transcriptional hubs confer phenotypic robustness

Multi-enhancer transcriptional hubs confer phenotypic robustness

We previously showed in Drosophila melanogaster embryos that low-affinity Ultrabithorax (Ubx)-responsive shavenbaby (svb) enhancers drive expression using localized transcriptional environments and that active svb enhancers on different chromosomes tended to colocalize (Tsai et al., 2017). Here, we...

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Bibliographic Details
Main Authors: Albert Tsai, Mariana RP Alves, Justin Crocker
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2019-07-01
Series:eLife
Subjects:
transcriptional regulation
hox genes
trancriptional enhancers
fluorescence imaging
phenotypical robustness
transcriptional hubs
Online Access:https://elifesciences.org/articles/45325

Internet

https://elifesciences.org/articles/45325

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