High protein copy number is required to suppress stochasticity in the cyanobacterial circadian clock

High protein copy number is required to suppress stochasticity in the cyanobacterial circadian clock

Circadian clocks must maintain their fidelity despite stochasticity arising from finite protein copy numbers. Here, the authors show that a small cyanobacterium relies on an environmentally driven timer likely because its low protein copy numbers cannot support an accurate free-running clock.

Bibliographic Details
Main Authors: Justin Chew, Eugene Leypunskiy, Jenny Lin, Arvind Murugan, Michael J. Rust
Format: Article
Language:English
Published: Nature Publishing Group 2018-08-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-018-05109-4
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spelling doaj-3a859e07eb4d4af4bc8e956db63488052021-05-11T10:29:44ZengNature Publishing GroupNature Communications2041-17232018-08-019111010.1038/s41467-018-05109-4High protein copy number is required to suppress stochasticity in the cyanobacterial circadian clockJustin Chew0Eugene Leypunskiy1Jenny Lin2Arvind Murugan3Michael J. Rust4Medical Scientist Training Program, Pritzker School of Medicine, University of ChicagoGraduate Program in Biophysical Sciences, University of ChicagoDepartment of Biochemistry and Molecular Biology, University of ChicagoDepartment of Physics, University of ChicagoDepartment of Physics, University of ChicagoCircadian clocks must maintain their fidelity despite stochasticity arising from finite protein copy numbers. Here, the authors show that a small cyanobacterium relies on an environmentally driven timer likely because its low protein copy numbers cannot support an accurate free-running clock.https://doi.org/10.1038/s41467-018-05109-4
collection DOAJ
language English
format Article
sources DOAJ
author Justin Chew
Eugene Leypunskiy
Jenny Lin
Arvind Murugan
Michael J. Rust
spellingShingle Justin Chew
Eugene Leypunskiy
Jenny Lin
Arvind Murugan
Michael J. Rust
High protein copy number is required to suppress stochasticity in the cyanobacterial circadian clock
Nature Communications
author_facet Justin Chew
Eugene Leypunskiy
Jenny Lin
Arvind Murugan
Michael J. Rust
author_sort Justin Chew
title High protein copy number is required to suppress stochasticity in the cyanobacterial circadian clock
title_short High protein copy number is required to suppress stochasticity in the cyanobacterial circadian clock
title_full High protein copy number is required to suppress stochasticity in the cyanobacterial circadian clock
title_fullStr High protein copy number is required to suppress stochasticity in the cyanobacterial circadian clock
title_full_unstemmed High protein copy number is required to suppress stochasticity in the cyanobacterial circadian clock
title_sort high protein copy number is required to suppress stochasticity in the cyanobacterial circadian clock
publisher Nature Publishing Group
series Nature Communications
issn 2041-1723
publishDate 2018-08-01
description Circadian clocks must maintain their fidelity despite stochasticity arising from finite protein copy numbers. Here, the authors show that a small cyanobacterium relies on an environmentally driven timer likely because its low protein copy numbers cannot support an accurate free-running clock.
url https://doi.org/10.1038/s41467-018-05109-4
work_keys_str_mv AT justinchew highproteincopynumberisrequiredtosuppressstochasticityinthecyanobacterialcircadianclock
AT eugeneleypunskiy highproteincopynumberisrequiredtosuppressstochasticityinthecyanobacterialcircadianclock
AT jennylin highproteincopynumberisrequiredtosuppressstochasticityinthecyanobacterialcircadianclock
AT arvindmurugan highproteincopynumberisrequiredtosuppressstochasticityinthecyanobacterialcircadianclock
AT michaeljrust highproteincopynumberisrequiredtosuppressstochasticityinthecyanobacterialcircadianclock
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