New-generation taxoid SB-T-1214 inhibits stem cell-related gene expression in 3D cancer spheroids induced by purified colon tumor-initiating cells

New-generation taxoid SB-T-1214 inhibits stem cell-related gene expression in 3D cancer spheroids induced by purified colon tumor-initiating cells

<p>Abstract</p> <p>Background</p> <p>Growing evidence suggests that the majority of tumors are organized hierarchically, comprising a population of tumor-initiating, or cancer stem cells (CSCs) responsible for tumor development, maintenance and resistance to drugs. Prev...

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Bibliographic Details
Main Authors: Rowehl Rebecca A, Savitt Anne G, Zhu Shu, Wang Hichao, Wang Yuan, Das Manisha, Zuniga Edison S, Botchkina Galina I, Leyfman Yan, Ju Jingfang, Shroyer Kenneth, Ojima Iwao
Format: Article
Language:English
Published: BMC 2010-07-01
Series:Molecular Cancer
Online Access:http://www.molecular-cancer.com/content/9/1/192

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