Tumor-suppressing effects of autophagy on hepatocellular carcinoma

Tumor-suppressing effects of autophagy on hepatocellular carcinoma

Evasion of apoptosis is one of the hallmarks of hepatocellular carcinoma (HCC) that results in treatment resistance. Recently, autophagy was reported to induce cell death in HCC, highlighting the tumor-suppressing effects of autophagy on HCC. This review summarizes our current understanding of the H...

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Main Authors: Lijun Pang, Kai Liu
Format: Article
Language:English
Published: KeAi Communications Co., Ltd. 2018-09-01
Series:Liver Research
Online Access:http://www.sciencedirect.com/science/article/pii/S2542568418300084
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spelling doaj-3a7757e095904634a7f94ce4669b200d2021-02-02T04:00:38ZengKeAi Communications Co., Ltd.Liver Research2542-56842018-09-0123157160Tumor-suppressing effects of autophagy on hepatocellular carcinomaLijun Pang0Kai Liu1Capital Medical University Affiliated Beijing YouAn Hospital, Beijing, China; Beijing Institute of Hepatology, Beijing, China; Beijing Precision Medicine and Transformation Engineering Technology Research Center of Hepatitis and Liver Cancer, Beijing, ChinaCapital Medical University Affiliated Beijing YouAn Hospital, Beijing, China; Beijing Institute of Hepatology, Beijing, China; Beijing Precision Medicine and Transformation Engineering Technology Research Center of Hepatitis and Liver Cancer, Beijing, China; Corresponding author. Capital Medical University Affiliated Beijing YouAn Hospital, Beijing, China.Evasion of apoptosis is one of the hallmarks of hepatocellular carcinoma (HCC) that results in treatment resistance. Recently, autophagy was reported to induce cell death in HCC, highlighting the tumor-suppressing effects of autophagy on HCC. This review summarizes our current understanding of the HCC-suppressing effects of macroautophagy (hereafter referred to as autophagy) to provide insights into the molecular mechanisms that may be essential for the development of autophagy-targeting therapeutic strategies for HCC. Keywords: Autophagy, Mitophagy, Cell death, Hepatocellular carcinoma (HCC), Damage-regulated autophagy modulator (DRAM)http://www.sciencedirect.com/science/article/pii/S2542568418300084
collection DOAJ
language English
format Article
sources DOAJ
author Lijun Pang
Kai Liu
spellingShingle Lijun Pang
Kai Liu
Tumor-suppressing effects of autophagy on hepatocellular carcinoma
Liver Research
author_facet Lijun Pang
Kai Liu
author_sort Lijun Pang
title Tumor-suppressing effects of autophagy on hepatocellular carcinoma
title_short Tumor-suppressing effects of autophagy on hepatocellular carcinoma
title_full Tumor-suppressing effects of autophagy on hepatocellular carcinoma
title_fullStr Tumor-suppressing effects of autophagy on hepatocellular carcinoma
title_full_unstemmed Tumor-suppressing effects of autophagy on hepatocellular carcinoma
title_sort tumor-suppressing effects of autophagy on hepatocellular carcinoma
publisher KeAi Communications Co., Ltd.
series Liver Research
issn 2542-5684
publishDate 2018-09-01
description Evasion of apoptosis is one of the hallmarks of hepatocellular carcinoma (HCC) that results in treatment resistance. Recently, autophagy was reported to induce cell death in HCC, highlighting the tumor-suppressing effects of autophagy on HCC. This review summarizes our current understanding of the HCC-suppressing effects of macroautophagy (hereafter referred to as autophagy) to provide insights into the molecular mechanisms that may be essential for the development of autophagy-targeting therapeutic strategies for HCC. Keywords: Autophagy, Mitophagy, Cell death, Hepatocellular carcinoma (HCC), Damage-regulated autophagy modulator (DRAM)
url http://www.sciencedirect.com/science/article/pii/S2542568418300084
work_keys_str_mv AT lijunpang tumorsuppressingeffectsofautophagyonhepatocellularcarcinoma
AT kailiu tumorsuppressingeffectsofautophagyonhepatocellularcarcinoma
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