| Summary: | Evasion of apoptosis is one of the hallmarks of hepatocellular carcinoma (HCC) that results in treatment resistance. Recently, autophagy was reported to induce cell death in HCC, highlighting the tumor-suppressing effects of autophagy on HCC. This review summarizes our current understanding of the HCC-suppressing effects of macroautophagy (hereafter referred to as autophagy) to provide insights into the molecular mechanisms that may be essential for the development of autophagy-targeting therapeutic strategies for HCC. Keywords: Autophagy, Mitophagy, Cell death, Hepatocellular carcinoma (HCC), Damage-regulated autophagy modulator (DRAM)
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