Primary Amyloidosis - In a Case with Normal Plasma Cell Counts
Amyloidosis is a group of disease that is characterized by the deposition of extracellular abnormal proteinaceous material (amyloid), in various organs. Amyloidosis involving the liver is common, and the radiological findings are often nonspecific. We present the case of a 40-year-old female who p...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
JCDR Research and Publications Private Limited
2017-07-01
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| Series: | Journal of Clinical and Diagnostic Research |
| Subjects: | |
| Online Access: | https://jcdr.net/articles/PDF/10241/26429_CE(RA1)_F(V0)_PF1(NE_DS_SS)_PFA(PNE).pdf |
| Summary: | Amyloidosis is a group of disease that is characterized by the deposition of extracellular abnormal proteinaceous material (amyloid),
in various organs. Amyloidosis involving the liver is common, and the radiological findings are often nonspecific. We present the
case of a 40-year-old female who presented with abdominal pain. Ultrasound abdomen was reported as massive hepatomegaly
with diffuse liver parenchymal disease. Bone marrow aspiration showed normomegaloblastic erythroid hyperplasia and plasma cells
were within normal limits (5%). Also, amorphous, eosinophilic fragmented to smudgy material within the interstitium of cell trails was
seen. Bone marrow biopsy and liver biopsy also showed similar kind of homogenous eosinophilic material. Both liver biopsy and
bone marrow biopsy were subjected to special stains which confirmed the presence of amyloid. The patient did not have clinical
or laboratory findings suggestive of any other organ involvement. Thus, we conclude that clinical and imaging presentations of
amyloidosis are often nonspecific, hence biopsy is always required to confirm the diagnosis. Amyloid deposits on bone marrow
aspiration are a rare occurrence and are often missed. It is an unusual sighting with very few studies mentioning its occurrence. |
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| ISSN: | 2249-782X 0973-709X |