Expression of Bcl-2 in Breast Cancer: Correlation with Clinicopathological Characteristics and Survival

• Main Authors: Filip Čečka, Helena Hornychová, Bohuslav Melichar, Aleš Ryška, Pavel Jandík, Jindřiška Mergancová, Hana Klozová-Urminská
• Format: Article
• Language: English
• Published: Karolinum Press 2008-01-01
• Series: Acta Medica
• Subjects: Breast cancer; bcl-2; Apoptosis; Prognostic factor; Neoadjuvant chemotherapy
• Online Access: https://actamedica.lfhk.cuni.cz/51/2/0107/

Breast cancer is the most common malignancy in women. It is an immensely heterogeneous disease, characterised by a broad variety of clinical development. The research in recent years has focused on finding new markers of prognosis. This study investigates the role of expression of the bcl-2 protein in breast cancer. We analysed bcl-2 expression in 57 women with primary breast carcinoma who were treated with neoadjuvant (primary) chemotherapy, followed by a surgical procedure. The bcl-2 expression was correlated with other clinicopathological characteristics of the tumour – histological grade, stage, expression of hormonal receptors, proliferation rate, and with the survival of the patients. No significant association of bcl-2 expression with either overall survival or disease free survival was found.