The rs74794265 SNP of the SREK1 Gene is Associated with COPD in Kashi, China

• Main Authors: Abudureheman Z, Li L, Zhong X, Xu J, Gong H, Yilamujiang S, Ren J, Xie C, Zheng A, Tuerxun D, Abudukadeer A, Aini P, Xu A, Zou X
• Format: Article
• Language: English
• Published: Dove Medical Press 2021-09-01
• Series: International Journal of COPD
• Subjects: copd; srek1 gene polymorphism; rs74794265 locus; uyghur population
• Online Access: https://www.dovepress.com/the-rs74794265-snp-of-the-srek1-gene-is-associated-with-copd-in-kashi--peer-reviewed-fulltext-article-COPD

Zulipikaer Abudureheman,1,* Li Li,2,* XueMei Zhong,2,* JingRan Xu,2 Hui Gong,1 Subinuer Yilamujiang,1 Jie Ren,2 ChengXin Xie,2 AiFang Zheng,2 Dilala Tuerxun,2 Ayiguzali Abudukadeer,2 Paierda Aini,2 AiMin Xu,3 XiaoGuang Zou2 1Department of Clinical Research Center of Infectious Diseases (Pulmonary Tuberculosis), First People’s Hospital of Kashi, Kashi, People’s Republic of China; 2Department of Respiratory and Critical Care Medicine, First People’s Hospital of Kashi, Kashi, People’s Republic of China; 3Department of Clinical Laboratory, First People’s Hospital of Kashi, Kashi, People’s Republic of China*These authors contributed equally to this workCorrespondence: AiMin Xu; XiaoGuang Zou Email [e-mail]; [e-mail]: Kashi city is situated near the Taklamakan desert and has a high incidence rate of chronic obstructive pulmonary disease (COPD). In this study, we aimed to explore the relationship between the SNP of the SREK1 gene locus rs74794265 and the susceptibility to COPD among the Uyghur population in Kashi, XinJiang, China.Methods: A total of 541 patients with COPD and 534 control subjects were included in this study. Sanger sequencing was used to analyze the SNP of the SREK1 gene locus rs74794265 site. The distribution of genotypes in different genetic models between the case and control group were analyzed by logistic regression analysis after adjusting for age, sex, and smoking history.Results: The SREK1 gene SNP locus rs74794265 included two genotypes, namely, C/C and C/T, of which C/C was the wildtype; The risk of COPD was significantly lower in patients with heterozygous C/T in rs74794265 [p=0.0236, OR=0.3677 (0.1547– 0.8742)], and the allele frequency of T was also significantly lower in the patient group [p=0.0245, OR=0.3728 (0.1577– 0.8811)]. The heterozygous C/T of rs74794265 among non-smoking COPD patients was significantly lower than other COPD patients [p=0.0298, OR=0.3217 (0.1156– 0.8949)], and there was no significant correlation of the heterozygous C/T genotype in smokers.Conclusion: We found that the rs74794265 heterozygous C/T genotype significantly reduces the risk of COPD. The C/T genotype is likely a protective factor for COPD in the Kashi region. We speculate that the occurrence of COPD in this area is probably more related to desert climate condition and genetic factors than smoking status.Keywords: COPD, SREK1 gene polymorphism, rs74794265 locus, Uyghur population