PAN-811 prevents chemotherapy-induced cognitive impairment and preserves neurogenesis in the hippocampus of adult rats.

PAN-811 prevents chemotherapy-induced cognitive impairment and preserves neurogenesis in the hippocampus of adult rats.

Chemotherapy-induced cognitive impairment (CICI) occurs in a substantial proportion of treated cancer patients, with no drug currently available for its therapy. This study investigated whether PAN-811, a ribonucleotide reductase inhibitor, can reduce cognitive impairment and related suppression of...

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Bibliographic Details
Main Authors: Zhi-Gang Jiang, Gordon Winocur, J Martin Wojtowicz, Olga Shevtsova, Steven Fuller, Hossein A Ghanbari
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2018-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC5785016?pdf=render

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http://europepmc.org/articles/PMC5785016?pdf=render

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