Anti-Allergic Inflammatory Activity of Interleukin-37 Is Mediated by Novel Signaling Cascades in Human Eosinophils

Anti-Allergic Inflammatory Activity of Interleukin-37 Is Mediated by Novel Signaling Cascades in Human Eosinophils

IL-1 family regulatory cytokine IL-37b can suppress innate immunity and inflammatory activity in inflammatory diseases. In this study, IL-37b showed remarkable in vitro suppression of inflammatory tumor necrosis factor-α, IL-1β, IL-6, CCL2, and CXCL8 production in the coculture of human primary eosi...

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Bibliographic Details
Main Authors: Jing Zhu, Jie Dong, Lu Ji, Peiyong Jiang, Ting Fan Leung, Dehua Liu, Lai Guan Ng, Miranda Sin-Man Tsang, Delong Jiao, Christopher Wai-Kei Lam, Chun-Kwok Wong
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-06-01
Series:Frontiers in Immunology
Subjects:
allergic asthma
eosinophils
interleukin-37
signal transduction
transcriptional profile
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2018.01445/full

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