Methadone Suppresses Neuronal Function and Maturation in Human Cortical Organoids

Methadone Suppresses Neuronal Function and Maturation in Human Cortical Organoids

Accumulating evidence has suggested that prenatal exposure to methadone causes multiple adverse effects on human brain development. Methadone not only suppresses fetal neurobehavior and alters neural maturation, but also leads to long-term neurological impairment. Due to logistical and ethical issue...

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Bibliographic Details
Main Authors: Wei Wu, Hang Yao, Ila Dwivedi, Priscilla D. Negraes, Helen W. Zhao, Juan Wang, Cleber A. Trujillo, Alysson R. Muotri, Gabriel G. Haddad
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-11-01
Series:Frontiers in Neuroscience
Subjects:
methadone
cortical organoid
iPSCs
neural function
ion channel
patch-clamp
Online Access:https://www.frontiersin.org/articles/10.3389/fnins.2020.593248/full

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