Proteolytic processed form of CXCL12 abolishes migration and induces apoptosis in neural stem cells in vitro

Proteolytic processed form of CXCL12 abolishes migration and induces apoptosis in neural stem cells in vitro

The subventricular zone (SVZ) of the adult mammalian brain hosts full potential neural stem cells (NSCs). NSCs are able to respond to extracellular signals in the brain, amplifying the pool of progenitor cells and giving rise to neuroblasts that show ability to migrate towards an injury site. These...

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Bibliographic Details
Main Authors: Taís Adelita, Roberta Sessa Stilhano, Sang Won Han, Giselle Zenker Justo, Marimelia Porcionatto
Format: Article
Language:English
Published: Elsevier 2017-07-01
Series:Stem Cell Research
Subjects:
CXCL12
CXCL12(5-67)
Adult neural stem cell
Migration
Apoptosis
In vitro study
Online Access:http://www.sciencedirect.com/science/article/pii/S1873506117301009

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