Quinolone resistance in Salmonella enterica serovar Typhi: Mechanisms, factors driving the spread of resistance, current epidemiological trends and clinical significance
The human restricted bacteria,Salmonella enterica serovar Typhi is the major cause of typhoid fever (or enteric fever), a characteristic severe systemic illness. In 2010, typhoid fever accounted for an estimated global burden of 27 million new cases and 200,000 deaths. For over two decades,...
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South Sudan Doctors' Association
2015-08-01
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doaj-3a2d2b5d76b64489b87d189893bedcf22020-11-24T23:51:21ZengSouth Sudan Doctors' AssociationSouth Sudan Medical Journal 2309-46052309-46132015-08-01836466Quinolone resistance in Salmonella enterica serovar Typhi: Mechanisms, factors driving the spread of resistance, current epidemiological trends and clinical significanceGasim Omer Elkhalifa Abd-Elfarag0Tropical & Infectious Diseases Student, Liverpool School of Tropical Medicine, UKThe human restricted bacteria,Salmonella enterica serovar Typhi is the major cause of typhoid fever (or enteric fever), a characteristic severe systemic illness. In 2010, typhoid fever accounted for an estimated global burden of 27 million new cases and 200,000 deaths. For over two decades, S. enterica serovar Typhi and other serovars have developed resistance to the first line antimicrobials (ampicillin, chloramphenicol, and co-trimoxazole). As a result of this multidrug resistance (MDR), quinolones became key antibiotics for treatment of Salmonella Typhi disease. Quinolones are a group of antimicrobials with a 4-quinolone nucleus. Quinolones target the bacterial enzymes DNA gyrase and topoisomerase IV, which are essential for DNA replication and transcription.http://www.southsudanmedicaljournal.com/archive/august-2015/quinolone-resistance-in-salmonella-enterica-serovar-typhi-mechanisms-factors-driving-the-spread-of-resistance-current-epidemiological-trends-and-clinical-significance.html |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Gasim Omer Elkhalifa Abd-Elfarag |
spellingShingle |
Gasim Omer Elkhalifa Abd-Elfarag Quinolone resistance in Salmonella enterica serovar Typhi: Mechanisms, factors driving the spread of resistance, current epidemiological trends and clinical significance South Sudan Medical Journal |
author_facet |
Gasim Omer Elkhalifa Abd-Elfarag |
author_sort |
Gasim Omer Elkhalifa Abd-Elfarag |
title |
Quinolone resistance in Salmonella enterica serovar Typhi: Mechanisms, factors driving the spread of resistance, current epidemiological trends and clinical significance |
title_short |
Quinolone resistance in Salmonella enterica serovar Typhi: Mechanisms, factors driving the spread of resistance, current epidemiological trends and clinical significance |
title_full |
Quinolone resistance in Salmonella enterica serovar Typhi: Mechanisms, factors driving the spread of resistance, current epidemiological trends and clinical significance |
title_fullStr |
Quinolone resistance in Salmonella enterica serovar Typhi: Mechanisms, factors driving the spread of resistance, current epidemiological trends and clinical significance |
title_full_unstemmed |
Quinolone resistance in Salmonella enterica serovar Typhi: Mechanisms, factors driving the spread of resistance, current epidemiological trends and clinical significance |
title_sort |
quinolone resistance in salmonella enterica serovar typhi: mechanisms, factors driving the spread of resistance, current epidemiological trends and clinical significance |
publisher |
South Sudan Doctors' Association |
series |
South Sudan Medical Journal |
issn |
2309-4605 2309-4613 |
publishDate |
2015-08-01 |
description |
The human restricted bacteria,Salmonella enterica serovar Typhi is the major cause of typhoid fever (or enteric fever), a characteristic severe systemic illness. In 2010, typhoid fever accounted for an estimated global burden of 27 million new cases and 200,000 deaths.
For over two decades, S. enterica serovar Typhi and other serovars have developed resistance to the first line antimicrobials (ampicillin, chloramphenicol, and co-trimoxazole). As a result of this multidrug resistance (MDR), quinolones became key antibiotics for treatment of Salmonella Typhi disease. Quinolones are a group of antimicrobials with a 4-quinolone nucleus. Quinolones target the bacterial enzymes DNA gyrase and topoisomerase IV, which are essential for DNA replication and transcription. |
url |
http://www.southsudanmedicaljournal.com/archive/august-2015/quinolone-resistance-in-salmonella-enterica-serovar-typhi-mechanisms-factors-driving-the-spread-of-resistance-current-epidemiological-trends-and-clinical-significance.html |
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