Quinolone resistance in Salmonella enterica serovar Typhi: Mechanisms, factors driving the spread of resistance, current epidemiological trends and clinical significance

The human restricted bacteria,Salmonella enterica serovar Typhi is the major cause of typhoid fever (or enteric fever), a characteristic severe systemic illness. In 2010, typhoid fever accounted for an estimated global burden of 27 million new cases and 200,000 deaths. For over two decades,...

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Main Author: Gasim Omer Elkhalifa Abd-Elfarag
Format: Article
Language:English
Published: South Sudan Doctors' Association 2015-08-01
Series:South Sudan Medical Journal
Online Access:http://www.southsudanmedicaljournal.com/archive/august-2015/quinolone-resistance-in-salmonella-enterica-serovar-typhi-mechanisms-factors-driving-the-spread-of-resistance-current-epidemiological-trends-and-clinical-significance.html
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spelling doaj-3a2d2b5d76b64489b87d189893bedcf22020-11-24T23:51:21ZengSouth Sudan Doctors' AssociationSouth Sudan Medical Journal 2309-46052309-46132015-08-01836466Quinolone resistance in Salmonella enterica serovar Typhi: Mechanisms, factors driving the spread of resistance, current epidemiological trends and clinical significanceGasim Omer Elkhalifa Abd-Elfarag0Tropical & Infectious Diseases Student, Liverpool School of Tropical Medicine, UKThe human restricted bacteria,Salmonella enterica serovar Typhi is the major cause of typhoid fever (or enteric fever), a characteristic severe systemic illness. In 2010, typhoid fever accounted for an estimated global burden of 27 million new cases and 200,000 deaths. For over two decades, S. enterica serovar Typhi and other serovars have developed resistance to the first line antimicrobials (ampicillin, chloramphenicol, and co-trimoxazole). As a result of this multidrug resistance (MDR), quinolones became key antibiotics for treatment of Salmonella Typhi disease. Quinolones are a group of antimicrobials with a 4-quinolone nucleus. Quinolones target the bacterial enzymes DNA gyrase and topoisomerase IV, which are essential for DNA replication and transcription.http://www.southsudanmedicaljournal.com/archive/august-2015/quinolone-resistance-in-salmonella-enterica-serovar-typhi-mechanisms-factors-driving-the-spread-of-resistance-current-epidemiological-trends-and-clinical-significance.html
collection DOAJ
language English
format Article
sources DOAJ
author Gasim Omer Elkhalifa Abd-Elfarag
spellingShingle Gasim Omer Elkhalifa Abd-Elfarag
Quinolone resistance in Salmonella enterica serovar Typhi: Mechanisms, factors driving the spread of resistance, current epidemiological trends and clinical significance
South Sudan Medical Journal
author_facet Gasim Omer Elkhalifa Abd-Elfarag
author_sort Gasim Omer Elkhalifa Abd-Elfarag
title Quinolone resistance in Salmonella enterica serovar Typhi: Mechanisms, factors driving the spread of resistance, current epidemiological trends and clinical significance
title_short Quinolone resistance in Salmonella enterica serovar Typhi: Mechanisms, factors driving the spread of resistance, current epidemiological trends and clinical significance
title_full Quinolone resistance in Salmonella enterica serovar Typhi: Mechanisms, factors driving the spread of resistance, current epidemiological trends and clinical significance
title_fullStr Quinolone resistance in Salmonella enterica serovar Typhi: Mechanisms, factors driving the spread of resistance, current epidemiological trends and clinical significance
title_full_unstemmed Quinolone resistance in Salmonella enterica serovar Typhi: Mechanisms, factors driving the spread of resistance, current epidemiological trends and clinical significance
title_sort quinolone resistance in salmonella enterica serovar typhi: mechanisms, factors driving the spread of resistance, current epidemiological trends and clinical significance
publisher South Sudan Doctors' Association
series South Sudan Medical Journal
issn 2309-4605
2309-4613
publishDate 2015-08-01
description The human restricted bacteria,Salmonella enterica serovar Typhi is the major cause of typhoid fever (or enteric fever), a characteristic severe systemic illness. In 2010, typhoid fever accounted for an estimated global burden of 27 million new cases and 200,000 deaths. For over two decades, S. enterica serovar Typhi and other serovars have developed resistance to the first line antimicrobials (ampicillin, chloramphenicol, and co-trimoxazole). As a result of this multidrug resistance (MDR), quinolones became key antibiotics for treatment of Salmonella Typhi disease. Quinolones are a group of antimicrobials with a 4-quinolone nucleus. Quinolones target the bacterial enzymes DNA gyrase and topoisomerase IV, which are essential for DNA replication and transcription.
url http://www.southsudanmedicaljournal.com/archive/august-2015/quinolone-resistance-in-salmonella-enterica-serovar-typhi-mechanisms-factors-driving-the-spread-of-resistance-current-epidemiological-trends-and-clinical-significance.html
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