Direct nose to brain delivery of small molecules: critical analysis of data from a standardized in vivo screening model in rats

Direct nose to brain delivery of small molecules: critical analysis of data from a standardized in vivo screening model in rats

The blood–brain barrier (BBB) is often a limiting factor for getting drugs in the brain. Bypassing the BBB by intranasal (IN), or also called nose to brain (NTB), route is an interesting and frequently investigated concept for brain drug delivery. However, despite the body of evidence for IN drug de...

Full description

Bibliographic Details
Main Authors: Deborah Dhuyvetter, Fetene Tekle, Maxim Nazarov, Rob J. Vreeken, Herman Borghys, Frederik Rombouts, Ilse Lenaerts, Astrid Bottelbergs
Format: Article
Language:English
Published: Taylor & Francis Group 2020-01-01
Series:Drug Delivery
Subjects:
drug delivery
nose to brain
intranasal
rat
brain targeting
direct cns transport
Online Access:http://dx.doi.org/10.1080/10717544.2020.1837291

Similar Items

Similar Items