Correlation of acid reflux and esophageal motility in patients with gastroesophageal reflux disease
Objective: To explore the relationship between acid reflux and esophageal motility in patients with gastroesophageal reflux disease. Methods: From January 2018 to December 2019, 80 patients with typical gastroesophageal reflux symptoms such as reflux and heartburn were randomly selected from the Dep...
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| Format: | Article |
| Language: | English |
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Editorial Board of Journal of Hainan Medical University
2020-11-01
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| Series: | Journal of Hainan Medical University |
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| Online Access: | http://www.hnykdxxb.com/PDF/202021/07.pdf |
| Summary: | Objective: To explore the relationship between acid reflux and esophageal motility in patients with gastroesophageal reflux disease. Methods: From January 2018 to December 2019, 80 patients with typical gastroesophageal reflux symptoms such as reflux and heartburn were randomly selected from the Department of Gastroenterology, First Affiliated Hospital of guangxi university of chinese medicine. The patients were divided into pathological group, sensitive group and physiological group based on the percentage of acid exposure time and reflux-symptom correlation. The GerdQ score, quality of life score, esophageal acid test and esophageal manometry related parameters of the three groups of patients were compared. Results: Compared with the sensitive group and the physiological group, the GerdQ score, DeMeester score, orthostatic acid reflux time, orthostatic acid reflux time, longest acid reflux time and acid reflux times in the pathological group were significantly higher.Sf-36 score, lower esophageal sphincter pressure and effective rate of deglutition were all significantly reduced, with statistically significant differences (P < 0.05).Compared with the physiological group, the GerdQ score of the sensitive group was higher. The sf-36 score was low, and the differences were statistically significant (P < 0.05). The acid indexes in the sensitive group were higher than those in the physiological group, but the differences were not statistically significant (P > 0.05).Compared with the physiological group, the distal contraction integral and the amplitude of the lower esophageal sphincter 3cm above the pathological group and the sensitive group decreased significantly (P < 0.05).There were no statistically significant differences in the length of the lower esophageal sphincter, the length of the lower esophageal sphincter in the abdominal segment, the amplitude of the upper esophageal sphincter at 7cm and 11cm and the peristaltic wave velocity of the esophageal body in the three groups (P > 0.05). Conclusion: the decrease of lower esophageal sphincter pressure is the key factor leading to pathological acid reflux, and acid reflux is closely related to distal contraction integral and peristaltic amplitude of 3cm on lower esophageal sphincter in patients with gastroesophageal reflux disease. |
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| ISSN: | 1007-1237 1007-1237 |