L-Asparaginase Exerts Neuroprotective Effects in an SH-SY5Y-A53T Model of Parkinson’s Disease by Regulating Glutamine Metabolism

L-Asparaginase Exerts Neuroprotective Effects in an SH-SY5Y-A53T Model of Parkinson’s Disease by Regulating Glutamine Metabolism

Background: Parkinson’s disease (PD) is the second most common neurodegenerative disease worldwide and involves deficiencies in alpha-synuclein (α-Syn) degradation. Effective therapeutic strategies for PD are urgently needed. L-asparaginase (L-ASNase) has been developed for therapeutic applications...

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Bibliographic Details
Main Authors: Qingxi Zhang, Yuyuan Gao, Jiahui Zhang, You Li, Jianing Chen, Rui Huang, Guixian Ma, Limin Wang, Yuhu Zhang, Kun Nie, Lijuan Wang
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-09-01
Series:Frontiers in Molecular Neuroscience
Subjects:
L-asparaginase
Parkinson’s disease
α-synuclein
glutamine
metabolism therapy
Online Access:https://www.frontiersin.org/article/10.3389/fnmol.2020.563054/full

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