Implementing sequence-based antigenic distance calculation into immunological shape space model
Abstract Background In 2009, a novel influenza vaccine was distributed worldwide to combat the H1N1 influenza “swine flu” pandemic. However, antibodies induced by the vaccine display differences in their specificity and cross-reactivity dependent on pre-existing immunity. Here, we present a computat...
Main Authors: | Christopher S. Anderson, Mark Y. Sangster, Hongmei Yang, Thomas J. Mariani, Sidhartha Chaudhury, David J. Topham |
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Format: | Article |
Language: | English |
Published: |
BMC
2020-06-01
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Series: | BMC Bioinformatics |
Subjects: | |
Online Access: | http://link.springer.com/article/10.1186/s12859-020-03594-3 |
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