Structures of tmRNA and SmpB as they transit through the ribosome

Structures of tmRNA and SmpB as they transit through the ribosome

Trans-translation, mediated by small protein B (SmpB) and transfer-messenger RNA (tmRNA), enables recycling of the ribosomes stalled on defective mRNAs in bacteria. Here, the authors report structures of the ribosome during trans-translation that reveal a translocation intermediate and elucidate the...

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Main Authors: Charlotte Guyomar, Gaetano D’Urso, Sophie Chat, Emmanuel Giudice, Reynald Gillet
Format: Article
Language:English
Published: Nature Publishing Group 2021-08-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-021-24881-4
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spelling doaj-3a1e36fd68b64f30af486fdffef9efd02021-08-15T11:40:22ZengNature Publishing GroupNature Communications2041-17232021-08-0112111410.1038/s41467-021-24881-4Structures of tmRNA and SmpB as they transit through the ribosomeCharlotte Guyomar0Gaetano D’Urso1Sophie Chat2Emmanuel Giudice3Reynald Gillet4Univ. Rennes, CNRS, Institut de Génétique et Développement de Rennes (IGDR) UMR 6290Univ. Rennes, CNRS, Institut de Génétique et Développement de Rennes (IGDR) UMR 6290Univ. Rennes, CNRS, Institut de Génétique et Développement de Rennes (IGDR) UMR 6290Univ. Rennes, CNRS, Institut de Génétique et Développement de Rennes (IGDR) UMR 6290Univ. Rennes, CNRS, Institut de Génétique et Développement de Rennes (IGDR) UMR 6290Trans-translation, mediated by small protein B (SmpB) and transfer-messenger RNA (tmRNA), enables recycling of the ribosomes stalled on defective mRNAs in bacteria. Here, the authors report structures of the ribosome during trans-translation that reveal a translocation intermediate and elucidate the movements of the tmRNA-SmpB complex in the ribosome.https://doi.org/10.1038/s41467-021-24881-4
collection DOAJ
language English
format Article
sources DOAJ
author Charlotte Guyomar
Gaetano D’Urso
Sophie Chat
Emmanuel Giudice
Reynald Gillet
spellingShingle Charlotte Guyomar
Gaetano D’Urso
Sophie Chat
Emmanuel Giudice
Reynald Gillet
Structures of tmRNA and SmpB as they transit through the ribosome
Nature Communications
author_facet Charlotte Guyomar
Gaetano D’Urso
Sophie Chat
Emmanuel Giudice
Reynald Gillet
author_sort Charlotte Guyomar
title Structures of tmRNA and SmpB as they transit through the ribosome
title_short Structures of tmRNA and SmpB as they transit through the ribosome
title_full Structures of tmRNA and SmpB as they transit through the ribosome
title_fullStr Structures of tmRNA and SmpB as they transit through the ribosome
title_full_unstemmed Structures of tmRNA and SmpB as they transit through the ribosome
title_sort structures of tmrna and smpb as they transit through the ribosome
publisher Nature Publishing Group
series Nature Communications
issn 2041-1723
publishDate 2021-08-01
description Trans-translation, mediated by small protein B (SmpB) and transfer-messenger RNA (tmRNA), enables recycling of the ribosomes stalled on defective mRNAs in bacteria. Here, the authors report structures of the ribosome during trans-translation that reveal a translocation intermediate and elucidate the movements of the tmRNA-SmpB complex in the ribosome.
url https://doi.org/10.1038/s41467-021-24881-4
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AT sophiechat structuresoftmrnaandsmpbastheytransitthroughtheribosome
AT emmanuelgiudice structuresoftmrnaandsmpbastheytransitthroughtheribosome
AT reynaldgillet structuresoftmrnaandsmpbastheytransitthroughtheribosome
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