Suppressor of IKKɛ is an essential negative regulator of pathological cardiac hypertrophy

Suppressor of IKKɛ is an essential negative regulator of pathological cardiac hypertrophy

Identifying pathways that cause pathological cardiac hypertrophy holds great therapeutic potential. Here the authors discover one such pathway and show that SIKE, an inhibitor of interferon signalling, prevents pathological but not physiological cardiac hypertrophy by interacting with TBK1 and modul...

Full description

Bibliographic Details
Main Authors: Ke-Qiong Deng, Aibing Wang, Yan-Xiao Ji, Xiao-Jing Zhang, Jing Fang, Yan Zhang, Peng Zhang, Xi Jiang, Lu Gao, Xue-Yong Zhu, Yichao Zhao, Lingchen Gao, Qinglin Yang, Xue-Hai Zhu, Xiang Wei, Jun Pu, Hongliang Li
Format: Article
Language:English
Published: Nature Publishing Group 2016-06-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/ncomms11432
id doaj-3a0ceb3a62dc4aea8e77bd44a26b3573
record_format Article
spelling doaj-3a0ceb3a62dc4aea8e77bd44a26b35732021-05-11T10:45:51ZengNature Publishing GroupNature Communications2041-17232016-06-017112110.1038/ncomms11432Suppressor of IKKɛ is an essential negative regulator of pathological cardiac hypertrophyKe-Qiong Deng0Aibing Wang1Yan-Xiao Ji2Xiao-Jing Zhang3Jing Fang4Yan Zhang5Peng Zhang6Xi Jiang7Lu Gao8Xue-Yong Zhu9Yichao Zhao10Lingchen Gao11Qinglin Yang12Xue-Hai Zhu13Xiang Wei14Jun Pu15Hongliang Li16Department of Cardiology, Renmin Hospital of Wuhan UniversityCollege of Veterinary Medicine, Hunan Agricultural UniversityDepartment of Cardiology, Renmin Hospital of Wuhan UniversityDepartment of Cardiology, Renmin Hospital of Wuhan UniversityDivision of Cardiothoracic and Vascular Surgery, Heart-Lung Transplantation Center, Sino-Swiss Heart-Lung Transplantation Institute, Tongji Hospital, Tongji Medical College, Huazhong University of Science and TechnologyDepartment of Cardiology, Renmin Hospital of Wuhan UniversityDepartment of Cardiology, Renmin Hospital of Wuhan UniversityDepartment of Cardiology, Renmin Hospital of Wuhan UniversityDepartment of Cardiology, Institute of Cardiovascular Disease, Union Hospital, Tongji Medical College, Huazhong University of Science and TechnologyDepartment of Cardiology, Renmin Hospital of Wuhan UniversityDepartment of Cardiology, Shanghai Renji Hospital, School of Medicine, Shanghai Jiaotong UniversityDepartment of Cardiology, Shanghai Renji Hospital, School of Medicine, Shanghai Jiaotong UniversityDepartment of Nutrition Sciences, University of Alabama at Birmingham, Birmingham, Alabama 35294-3360, USADivision of Cardiothoracic and Vascular Surgery, Heart-Lung Transplantation Center, Sino-Swiss Heart-Lung Transplantation Institute, Tongji Hospital, Tongji Medical College, Huazhong University of Science and TechnologyDivision of Cardiothoracic and Vascular Surgery, Heart-Lung Transplantation Center, Sino-Swiss Heart-Lung Transplantation Institute, Tongji Hospital, Tongji Medical College, Huazhong University of Science and TechnologyDepartment of Cardiology, Shanghai Renji Hospital, School of Medicine, Shanghai Jiaotong UniversityDepartment of Cardiology, Renmin Hospital of Wuhan UniversityIdentifying pathways that cause pathological cardiac hypertrophy holds great therapeutic potential. Here the authors discover one such pathway and show that SIKE, an inhibitor of interferon signalling, prevents pathological but not physiological cardiac hypertrophy by interacting with TBK1 and modulating the TBK1/AKT signalling in rodents and monkeys.https://doi.org/10.1038/ncomms11432
collection DOAJ
language English
format Article
sources DOAJ
author Ke-Qiong Deng
Aibing Wang
Yan-Xiao Ji
Xiao-Jing Zhang
Jing Fang
Yan Zhang
Peng Zhang
Xi Jiang
Lu Gao
Xue-Yong Zhu
Yichao Zhao
Lingchen Gao
Qinglin Yang
Xue-Hai Zhu
Xiang Wei
Jun Pu
Hongliang Li
spellingShingle Ke-Qiong Deng
Aibing Wang
Yan-Xiao Ji
Xiao-Jing Zhang
Jing Fang
Yan Zhang
Peng Zhang
Xi Jiang
Lu Gao
Xue-Yong Zhu
Yichao Zhao
Lingchen Gao
Qinglin Yang
Xue-Hai Zhu
Xiang Wei
Jun Pu
Hongliang Li
Suppressor of IKKɛ is an essential negative regulator of pathological cardiac hypertrophy
Nature Communications
author_facet Ke-Qiong Deng
Aibing Wang
Yan-Xiao Ji
Xiao-Jing Zhang
Jing Fang
Yan Zhang
Peng Zhang
Xi Jiang
Lu Gao
Xue-Yong Zhu
Yichao Zhao
Lingchen Gao
Qinglin Yang
Xue-Hai Zhu
Xiang Wei
Jun Pu
Hongliang Li
author_sort Ke-Qiong Deng
title Suppressor of IKKɛ is an essential negative regulator of pathological cardiac hypertrophy
title_short Suppressor of IKKɛ is an essential negative regulator of pathological cardiac hypertrophy
title_full Suppressor of IKKɛ is an essential negative regulator of pathological cardiac hypertrophy
title_fullStr Suppressor of IKKɛ is an essential negative regulator of pathological cardiac hypertrophy
title_full_unstemmed Suppressor of IKKɛ is an essential negative regulator of pathological cardiac hypertrophy
title_sort suppressor of ikkɛ is an essential negative regulator of pathological cardiac hypertrophy
publisher Nature Publishing Group
series Nature Communications
issn 2041-1723
publishDate 2016-06-01
description Identifying pathways that cause pathological cardiac hypertrophy holds great therapeutic potential. Here the authors discover one such pathway and show that SIKE, an inhibitor of interferon signalling, prevents pathological but not physiological cardiac hypertrophy by interacting with TBK1 and modulating the TBK1/AKT signalling in rodents and monkeys.
url https://doi.org/10.1038/ncomms11432
work_keys_str_mv AT keqiongdeng suppressorofikkɛisanessentialnegativeregulatorofpathologicalcardiachypertrophy
AT aibingwang suppressorofikkɛisanessentialnegativeregulatorofpathologicalcardiachypertrophy
AT yanxiaoji suppressorofikkɛisanessentialnegativeregulatorofpathologicalcardiachypertrophy
AT xiaojingzhang suppressorofikkɛisanessentialnegativeregulatorofpathologicalcardiachypertrophy
AT jingfang suppressorofikkɛisanessentialnegativeregulatorofpathologicalcardiachypertrophy
AT yanzhang suppressorofikkɛisanessentialnegativeregulatorofpathologicalcardiachypertrophy
AT pengzhang suppressorofikkɛisanessentialnegativeregulatorofpathologicalcardiachypertrophy
AT xijiang suppressorofikkɛisanessentialnegativeregulatorofpathologicalcardiachypertrophy
AT lugao suppressorofikkɛisanessentialnegativeregulatorofpathologicalcardiachypertrophy
AT xueyongzhu suppressorofikkɛisanessentialnegativeregulatorofpathologicalcardiachypertrophy
AT yichaozhao suppressorofikkɛisanessentialnegativeregulatorofpathologicalcardiachypertrophy
AT lingchengao suppressorofikkɛisanessentialnegativeregulatorofpathologicalcardiachypertrophy
AT qinglinyang suppressorofikkɛisanessentialnegativeregulatorofpathologicalcardiachypertrophy
AT xuehaizhu suppressorofikkɛisanessentialnegativeregulatorofpathologicalcardiachypertrophy
AT xiangwei suppressorofikkɛisanessentialnegativeregulatorofpathologicalcardiachypertrophy
AT junpu suppressorofikkɛisanessentialnegativeregulatorofpathologicalcardiachypertrophy
AT hongliangli suppressorofikkɛisanessentialnegativeregulatorofpathologicalcardiachypertrophy
_version_ 1721447601059921920

Similar Items