Effects of pro-inflammatory cytokines on expression of kynurenine pathway enzymes in human dermal fibroblasts

Effects of pro-inflammatory cytokines on expression of kynurenine pathway enzymes in human dermal fibroblasts

<p>Abstract</p> <p>Background</p> <p>The kynurenine pathway (KP) is the main route of tryptophan degradation in the human body and generates several neuroactive and immunomodulatory metabolites. Altered levels of KP-metabolites have been observed in neuropsychiatric and...

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Main Authors: Kegel Magdalena, Kocki Tomasz, Urbanska Ewa M, Owe-Larsson Björn, Mann Amandeep, Johansson Anne-Sofie, Asp Linnéa, Engberg Göran, Lundkvist Gabriella BS, Karlsson Håkan
Format: Article
Language:English
Published: BMC 2011-10-01
Series:Journal of Inflammation
Subjects:
human
fibroblast
kynurenine pathway
gene expression
cytokine
Online Access:http://www.journal-inflammation.com/content/8/1/25

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