DISSECT Method Using PNA-LNA Clamp Improves Detection of EGFR T790m Mutation.

DISSECT Method Using PNA-LNA Clamp Improves Detection of EGFR T790m Mutation.

Non-small cell lung cancer (NSCLC) patients treated with small molecule EGFR inhibitors, such as gefitinib, frequently develop drug resistance due to the presence of secondary mutations like the T790M mutation on EGFR exon 20. These mutations may originate from small subclonal populations in the pri...

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Bibliographic Details
Main Authors:	Minakshi Guha, Elena Castellanos-Rizaldos, G Mike Makrigiorgos
Format:	Article
Language:	English
Published:	Public Library of Science (PLoS) 2013-01-01
Series:	PLoS ONE
Online Access:	http://europepmc.org/articles/PMC3689726?pdf=render

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