4-Methyl-2,2-dioxo-1H-2λ6,1-benzothiazine-3-carboxylic Acid. Peculiarities of Preparation, Structure, and Biological Properties

4-Methyl-2,2-dioxo-1H-2λ6,1-benzothiazine-3-carboxylic Acid. Peculiarities of Preparation, Structure, and Biological Properties

In order to determine the regularities of the structure–analgesic activity relationship, the peculiarities of obtaining, the spatial structure, and biological properties of 4-methyl-2,2-dioxo-1H-2λ6,1-benzothiazine-3-carboxylic acid and some of its derivatives have been studied. Using nuclear magnet...

Full description

Bibliographic Details
Main Authors:	Igor V. Ukrainets, Ganna M. Hamza, Anna A. Burian, Svitlana V. Shishkina, Natali I. Voloshchuk, Oxana V. Malchenko
Format:	Article
Language:	English
Published:	Österreichische Apotheker-Verlagsgesellschaft m. b. H. 2018-03-01
Series:	Scientia Pharmaceutica
Subjects:	esters hydrolysis 4-methyl-2,2-dioxo-1H-2λ6,1-benzothiazine-3-carboxylic acid 2,1-benzothiazine crystal structure anti-inflammatory action analgesic activity
Online Access:	http://www.mdpi.com/2218-0532/86/1/9

Similar Items

Synthesis, Crystal Structure, and Biological Activity of Ethyl 4-Methyl-2,2-dioxo-1H-2λ6,1-benzothiazine-3-carboxylate Polymorphic Forms
by: Igor V. Ukrainets, et al.
Published: (2018-05-01)

New Synthesis, Structure and Analgesic Properties of Methyl 1-R-4-Methyl-2,2-Dioxo-1H-2λ6,1-Benzothiazine-3-Carboxylates
by: Liliana Azotla-Cruz, et al.
Published: (2017-01-01)

Molecular Conformations and Biological Activity of <i>N</i>-Hetaryl(aryl)alkyl-4-methyl-2,2-dioxo-1<i>H</i>-2λ<sup>6</sup>,1-benzothiazine-3-carboxamides
by: Igor V. Ukrainets, et al.
Published: (2018-11-01)

Synthesis and Regularities of the Structure–Activity Relationship in a Series of <i>N</i>-Pyridyl-4-methyl-2,2-dioxo-1<i>H</i>-2λ<sup>6</sup>,1-benzothiazine-3-carboxamides
by: Igor V. Ukrainets, et al.
Published: (2019-05-01)

The Crystal Structure of <i>N</i>-(1-Arylethyl)-4-methyl- 2,2-dioxo-1<i>H</i>-2λ<sup>6</sup>,1-benzothiazine-3-carboxamides as the Factor Determining Biological Activity Thereof
by: Igor V. Ukrainets, et al.
Published: (2019-04-01)

Methyl 4-Hydroxy-2,2-Dioxo-1<i>H</i>-2λ<sup>6</sup>,1-Benzothiazine-3-Carboxylate and Its Analogs Modified in the Benzene Moiety of the Molecule as New Analgesics
by: Igor V. Ukrainets, et al.
Published: (2020-03-01)

Synthesis, Spatial Structure and Analgesic Activity of Sodium 3-Benzylaminocarbonyl-1-methyl-2,2-dioxo-1H-2λ6,1-benzothiazin-4-olate Solvates
by: Igor V. Ukrainets, et al.
Published: (2016-10-01)

Molecular and crystal structure of methyl 4-methyl-2,2-dioxo-1H-2λ6,1-benzothiazine-3-carboxylate
by: Svitlana Shishkina, et al.
Published: (2018-09-01)

Methyl 5-chloro-4-hydroxy-2,2-dioxo-1H-2λ6,1-benzothiazine-3-carboxylate: structure and Hirshfeld surface analysis
by: Svitlana V. Shishkina, et al.
Published: (2020-10-01)

Synthesis and antimicrobial activities of novel 1,4-benzothiazine derivatives
by: Vijay V. Dabholkar, et al.
Published: (2016-09-01)

On the application of knoevenagel condensation for the synthesis of benzylidene benzothiazine compounds and structural study
by: Souza Ana Maria Alves de, et al.
Published: (2006-01-01)

On the application of knoevenagel condensation for the synthesis of benzylidene benzothiazine compounds and structural study
by: Ana Maria Alves de Souza, et al.
Published: (2006-10-01)

Evaluation of 1,2-Benzothiazine 1,1-dioxide Derivatives In Vitro Activity towards Clinical-Relevant Microorganisms and Fibroblasts
by: Ruth K. Dudek-Wicher, et al.
Published: (2020-07-01)

Structural Studies of 2-Pentyl/Pentenyl-Substituted Methyl 4-Hydroxy-2H-1,2-Benzothiazine-3-Carboxylate-1,1-Dioxide
by: Muhammad Nadeem ARSHAD, et al.
Published: (2012-03-01)

Synthesis and Antimicrobial Activity of 1,2-Benzothiazine Derivatives
by: Chandani Patel, et al.
Published: (2016-06-01)

Synthesis and antibacterial activity of new 1,2,3-triazolylmethyl-2H-1,4-benzothiazin-3(4H)-one derivatives
by: Mohamed Ellouz, et al.
Published: (2018-11-01)

(R)-(−)-2-[(5-Oxido-5-phenyl-5λ4-isoquino[4,3-c][2,1]benzothiazin-12-yl)amino]benzonitrile
by: Marcus Frings, et al.
Published: (2014-08-01)

4-Benzyl-2-(4-chlorobenzylidene)-3,4-dihydro-2H-1,4-benzothiazin-3(4H)-one
by: Mohamed Ellouz, et al.
Published: (2016-05-01)

(Z)-2-(2-Chlorobenzylidene)-4-(prop-2-ynyl)-2H-1,4-benzothiazin-3(4H)-one
by: Nada Kheira Sebbar, et al.
Published: (2017-06-01)

2-[(2Z)-2-Benzylidene-3-oxo-3,4-dihydro-2H-1,4-benzothiazin-4-yl]acetic acid
by: Nada Kheira Sebbar, et al.
Published: (2016-06-01)

(Z)-4-n-Butyl-2-(4-chlorobenzylidene)-2H-1,4-benzothiazin-3(4H)-one
by: Mohamed Ellouz, et al.
Published: (2017-06-01)

Efficient synthesis of benzothiazine and acrylamide compounds
by: Ana Maria Alves Souza, et al.
Published: (2010-01-01)

2-Amino- and 2-Alkylthio-4H-3,1-benzothiazin-4-ones: Synthesis, Interconversion and Enzyme Inhibitory Activities
by: Hans-Georg HÃƒÂ¤cker, et al.
Published: (2009-01-01)

4-Methyl-3,4-dihydro-2H-1,4-benzothiazin-3-one
by: Mohamed Ellouz, et al.
Published: (2017-02-01)

Synthesis and α-Glucosidase Inhibition Activity of 2-[3-(Benzoyl/4-bromobenzoyl)-4-hydroxy-1,1-dioxido-2<i>H</i>-benzo[<i>e</i>][1,2]thiazin-2-yl]-<i>N</i>-arylacetamides: An In Silico and Biochemical Approach
by: Furqan Ahmad Saddique, et al.
Published: (2021-05-01)

(Z)-2-Benzylidene-3-n-butoxy-2H-1,4-benzothiazine
by: Nada Kheira Sebbar, et al.
Published: (2017-06-01)

Molecular and crystal structure of 5,9-dimethyl-5H-pyrano[3,2-c:5,6-c′]bis[2,1-benzothiazin]-7(9H)-one 6,6,8,8-tetroxide dimethylformamide monosolvate
by: Andrii Rybalka, et al.
Published: (2019-07-01)

(2Z)-2-(4-Chlorobenzylidene)-4-[2-(2-oxooxazoliden-3-yl)ethyl]-3,4-dihydro-2H-1,4-benzothiazin-3-one
by: Mohamed Ellouz, et al.
Published: (2017-05-01)

Synthesis, characterization and thermodynamic studies of complexes of dimethyl, diethyl, and diphenyltin(IV) dichlorides with (2H)-1,4-benzothiazine-2,3-(4H)-dione dioxime
by: Leyla Shabani, et al.
Published: (2012-12-01)

Sulfoximines-Assisted Rh(III)-Catalyzed C–H Activation and Intramolecular Annulation for the Synthesis of Fused Isochromeno-1,2-Benzothiazines Scaffolds under Room Temperature
by: Bao Wang, et al.
Published: (2020-05-01)

Synthesis of 1,4-benzothiazinones from acylpyruvic acids or furan-2,3-diones and o-aminothiophenol
by: Ekaterina E. Stepanova, et al.
Published: (2020-09-01)

3,1-Benzothiazines, 1,4-Benzodioxines and 1,4-Benzoxazines as Inhibitors of Matriptase-2: Outcome of a Focused Screening Approach
by: Polya G. Roydeva, et al.
Published: (2016-01-01)

New simple synthesis of ring-fused 4-alkyl-4H-3,1-benzothiazine-2-thiones: Direct formation from carbon disulfide and (E)-3-(2-aminoaryl)acrylates or (E)-3-(2-aminoaryl)acrylonitriles
by: Qiuping Ding, et al.
Published: (2013-03-01)

Crystal structure of methyl 1-allyl-4-methyl-1H-benzo[c][1,2]thiazine-3-carboxylate 2,2-dioxide
by: Liliana Azotla-Cruz, et al.
Published: (2016-11-01)

SYNTHESIS AND ANTIBACTERIAL ACTIVITY OF NEW (Z)-2-(BENZYLIDENE)-3,4-DIHYDRO-2H-[1,4]-BENZOTHIAZIN-3-ONE D-GLUCOSE DERIVATIVES
by: MOHAMED ELLOUZ, et al.
Published: (2019-12-01)

Crystal structure of (Z)-ethyl 2-{5-[(2-benzylidene-3-oxo-2,3-dihydrobenzo[b][1,4]thiazin-4-yl)methyl]-1H-1,2,3-triazol-1-yl}acetate
by: M. Ellouz, et al.
Published: (2015-12-01)

Ethyl 3-methyl-1-oxo-4H-1,4-benzothiazine-2-carboxylate monohydrate
by: Yamna Baryala, et al.
Published: (2018-06-01)

Crystal structure of 2-(4-methylphenyl)-4H-1,3-benzothiazine
by: N. C. Sandhya, et al.
Published: (2015-02-01)

Crystal structure, Hirshfeld surface analysis, interaction energy and DFT studies of (2Z)-2-(2,4-dichlorobenzylidene)-4-nonyl-3,4-dihydro-2H-1,4-benzothiazin-3-one
by: Brahim Hni, et al.
Published: (2020-02-01)

A Direct and an Efficient Regioselective Synthesis of 1,2-Benzothiazine 1,1-Dioxides, <i>β</i>-Carbolinones, Indolo[2,3-<i>c</i>]pyran-1-ones, Indolo[3,2-<i>c</i>]pyran-1-ones, Thieno[2,3-<i>c</i>]pyran-7-ones and Pyrano[3’,4’:4,5]imidazo[1,2-<i>a</i>]pyridin-1-ones via Tandem Stille/Heterocyclization Reaction
by: Badr Jismy, et al.
Published: (2020-11-01)