FGF1ΔHBS prevents diabetic cardiomyopathy by maintaining mitochondrial homeostasis and reducing oxidative stress via AMPK/Nur77 suppression

FGF1ΔHBS prevents diabetic cardiomyopathy by maintaining mitochondrial homeostasis and reducing oxidative stress via AMPK/Nur77 suppression

Abstract As a classically known mitogen, fibroblast growth factor 1 (FGF1) has been found to exert other pleiotropic functions such as metabolic regulation and myocardial protection. Here, we show that serum levels of FGF1 were decreased and positively correlated with fraction shortening in diabetic...

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Bibliographic Details
Main Authors: Dezhong Wang, Yuan Yin, Shuyi Wang, Tianyang Zhao, Fanghua Gong, Yushuo Zhao, Beibei Wang, Yuli Huang, Zizhao Cheng, Guanghui Zhu, Zengshou Wang, Yang Wang, Jun Ren, Guang Liang, Xiaokun Li, Zhifeng Huang
Format: Article
Language:English
Published: Nature Publishing Group 2021-03-01
Series:Signal Transduction and Targeted Therapy
Online Access:https://doi.org/10.1038/s41392-021-00542-2

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