Association of <i>TLR4</i> and <i>CARD15/NOD2</i> polymorphisms with SCC in Holstein–Friesian cattle
<i>Mastitis</i> is one of the most important dairy cattle diseases which results in economic losses in dairy production. <i>Mastitis</i> cases can be classified as subclinical or clinical. All forms of <i>mastitis</i> lead to changes in milk composition and induce...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
| Published: |
Copernicus Publications
2015-07-01
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| Series: | Archives Animal Breeding |
| Online Access: | http://www.arch-anim-breed.net/58/293/2015/aab-58-293-2015.pdf |
| Summary: | <i>Mastitis</i> is one of the most important dairy cattle diseases which results in economic
losses in dairy production. <i>Mastitis</i> cases can be classified as subclinical or
clinical. All forms of <i>mastitis</i> lead to changes in milk composition and induce an
increase in somatic cell count (SCC). SCC is a very important and basic
indicator of udder health. An increase in SCC is usually caused by the
immune response to the invasion of pathogens contributing to <i>mastitis</i>. The aim of this
study was to investigate associations between the polymorphisms of selected
genes (<i>TLR4</i> and <i>CARD15/NOD2</i>) whose products are involved in the identification of
pathogen-associated molecular patterns (PAMPs) during the innate immune
response to infection, and immunity to <i>mastitis</i> expressed as SCC. The genes under
study were also examined for epistatic effects as well as effects of
interactions with parity and stages of lactation. In all the studied classes,
allele G of <i>TLR4</i> had a favourable additive effect with negative values,
contributing to a lower lnSCC. Allele A of <i>CARD15/NOD2</i> had a desirable additive effect
which varied with time and the changing internal environment during
lactation. With regard to the dominance effect, allele A of <i>CARD15/NOD2</i> was found to be
significantly associated with a higher SCC in milk in the first lactation
and in the third stage of each single lactation. Moreover, statistically
significant epistatic effects were found, in particular additive–additive
and dominance–additive interactions were favourably associated with SCC
which was lower than expected in the case of no epistasis. |
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| ISSN: | 0003-9438 2363-9822 |