Impact of repeated nasal sampling on detection and quantification of SARS-CoV-2

Impact of repeated nasal sampling on detection and quantification of SARS-CoV-2

Abstract The impact of repeated sample collection on COVID-19 test performance is unknown. The FDA and CDC currently recommend the primary collection of diagnostic samples to minimize the perceived risk of false-negative findings. We therefore evaluated the association between repeated sample collec...

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Bibliographic Details
Main Authors: Joshua M. Levy, Jennifer K. Frediani, Erika A. Tyburski, Anna Wood, Janet Figueroa, Russell R. Kempker, Paulina A. Rebolledo, Mark D. Gonzalez, Julie Sullivan, Miriam B. Vos, Jared O’Neal, Greg S. Martin, Wilbur A. Lam, Jesse J. Waggoner
Format: Article
Language:English
Published: Nature Publishing Group 2021-07-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-021-94547-0
Description
Summary:Abstract The impact of repeated sample collection on COVID-19 test performance is unknown. The FDA and CDC currently recommend the primary collection of diagnostic samples to minimize the perceived risk of false-negative findings. We therefore evaluated the association between repeated sample collection and test performance among 325 symptomatic patients undergoing COVID-19 testing in Atlanta, GA. High concordance was found between consecutively collected mid-turbinate samples with both molecular (n = 74, 100% concordance) and antigen-based (n = 147, 97% concordance, kappa = 0.95, CI = 0.88–1.00) diagnostic assays. Repeated sample collection does not decrease COVID-19 test performance, demonstrating that multiple samples can be collected for assay validation and clinical diagnosis.
ISSN:2045-2322

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