The Diarylheptanoid Curcumin Induces MYC Inhibition and Cross-Links This Oncoprotein to the Coactivator TRRAP

The Diarylheptanoid Curcumin Induces MYC Inhibition and Cross-Links This Oncoprotein to the Coactivator TRRAP

The c-Myc protein (MYC) is a transcription factor with strong oncogenic potential controlling fundamental cellular processes. In most human tumors, MYC is overexpressed by enhanced transcriptional activation, gene amplification, chromosomal rearrangements, or increased protein stabilization. To phar...

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Bibliographic Details
Main Authors: Alexander Mödlhammer, Sandra Pfurtscheller, Andreas Feichtner, Markus Hartl, Rainer Schneider
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-04-01
Series:Frontiers in Oncology
Subjects:
gene regulation
transcription control
cancer
protein modification
cell transformation
Online Access:https://www.frontiersin.org/articles/10.3389/fonc.2021.660481/full

Internet

https://www.frontiersin.org/articles/10.3389/fonc.2021.660481/full

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