Context Dependent Effects of Chimeric Peptide Morpholino Conjugates Contribute to Dystrophin Exon-skipping Efficiency

Context Dependent Effects of Chimeric Peptide Morpholino Conjugates Contribute to Dystrophin Exon-skipping Efficiency

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We have recently reported that cell-penetrating peptides (CPPs) and novel chimeric peptides containing CPP (referred as B peptide) and muscle-targeting peptide (referred as MSP) motifs significantly improve the systemic exon-skipping activity of morpholino phosphorodiamidate oligomers (PMOs) in dyst...

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Bibliographic Details
Main Authors: HaiFang Yin, Prisca Boisguerin, Hong M Moulton, Corinne Betts, Yiqi Seow, Jordan Boutilier, Qingsong Wang, Anthony Walsh, Bernard Lebleu, Matthew JA Wood
Format: Article
Language:English
Published: Elsevier 2013-01-01
Series:Molecular Therapy: Nucleic Acids
Subjects:
antisense oligonucleotide
chimeric peptide conjugate
Duchenne muscular dystrophy
exon skipping
Online Access:http://www.sciencedirect.com/science/article/pii/S2162253116301834

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http://www.sciencedirect.com/science/article/pii/S2162253116301834

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