A Case of Granulomatosis with Polyangiitis (Wegener’s Granulomatosis) Presenting with Marked Inflamed Tracheobronchial Mucosa

A Case of Granulomatosis with Polyangiitis (Wegener’s Granulomatosis) Presenting with Marked Inflamed Tracheobronchial Mucosa

A 70-year-old man was admitted to our hospital because of weight loss and persistent dry cough. Chest radiograph and CT showed multiple infiltrates in the bilateral upper lobes and the remarkably thickened bronchial walls. Bronchoscopy revealed diffuse erythema and edema of the tracheobronchial muco...

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Main Authors: Teruaki Nishiuma, Hisashi Ohnishi, Sho Yoshimura, Saori Kinami, Susumu Sakamoto
Format: Article
Language:English
Published: Hindawi Limited 2013-01-01
Series:Case Reports in Medicine
Online Access:http://dx.doi.org/10.1155/2013/208194
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spelling doaj-39d56c9c6b91481e839d11ad664806d52020-11-25T01:11:51ZengHindawi LimitedCase Reports in Medicine1687-96271687-96352013-01-01201310.1155/2013/208194208194A Case of Granulomatosis with Polyangiitis (Wegener’s Granulomatosis) Presenting with Marked Inflamed Tracheobronchial MucosaTeruaki Nishiuma0Hisashi Ohnishi1Sho Yoshimura2Saori Kinami3Susumu Sakamoto4Department of Respiratory Medicine, Akashi Medical Center, 743-33 Yagi, Okubo-cho, Akashi, Hyogo 674-0063, JapanDepartment of Respiratory Medicine, Akashi Medical Center, 743-33 Yagi, Okubo-cho, Akashi, Hyogo 674-0063, JapanDepartment of Respiratory Medicine, Akashi Medical Center, 743-33 Yagi, Okubo-cho, Akashi, Hyogo 674-0063, JapanDepartment of Internal Medicine, Akashi Medical Center, 743-33 Yagi, Okubo-cho, Akashi, Hyogo 674-0063, JapanDepartment of Internal Medicine, Akashi Medical Center, 743-33 Yagi, Okubo-cho, Akashi, Hyogo 674-0063, JapanA 70-year-old man was admitted to our hospital because of weight loss and persistent dry cough. Chest radiograph and CT showed multiple infiltrates in the bilateral upper lobes and the remarkably thickened bronchial walls. Bronchoscopy revealed diffuse erythema and edema of the tracheobronchial mucosa without any ulcerous legions. Serum MPO-ANCA was positive (155 EU). Transbronchial biopsy was performed and revealed necrotic granulomas with multinucleated giant cells in the bronchial/bronchiolar and parenchymal lesions. Thus, we diagnosed it as a localized form of granulomatosis with polyangiitis (GPA, Wegener’s granulomatosis). After treatment with corticosteroid and cyclophosphamide, the bronchial findings were entirely resolved. We report here a rare case of GPA presenting with markedly inflamed tracheobronchial mucosa.http://dx.doi.org/10.1155/2013/208194
collection DOAJ
language English
format Article
sources DOAJ
author Teruaki Nishiuma
Hisashi Ohnishi
Sho Yoshimura
Saori Kinami
Susumu Sakamoto
spellingShingle Teruaki Nishiuma
Hisashi Ohnishi
Sho Yoshimura
Saori Kinami
Susumu Sakamoto
A Case of Granulomatosis with Polyangiitis (Wegener’s Granulomatosis) Presenting with Marked Inflamed Tracheobronchial Mucosa
Case Reports in Medicine
author_facet Teruaki Nishiuma
Hisashi Ohnishi
Sho Yoshimura
Saori Kinami
Susumu Sakamoto
author_sort Teruaki Nishiuma
title A Case of Granulomatosis with Polyangiitis (Wegener’s Granulomatosis) Presenting with Marked Inflamed Tracheobronchial Mucosa
title_short A Case of Granulomatosis with Polyangiitis (Wegener’s Granulomatosis) Presenting with Marked Inflamed Tracheobronchial Mucosa
title_full A Case of Granulomatosis with Polyangiitis (Wegener’s Granulomatosis) Presenting with Marked Inflamed Tracheobronchial Mucosa
title_fullStr A Case of Granulomatosis with Polyangiitis (Wegener’s Granulomatosis) Presenting with Marked Inflamed Tracheobronchial Mucosa
title_full_unstemmed A Case of Granulomatosis with Polyangiitis (Wegener’s Granulomatosis) Presenting with Marked Inflamed Tracheobronchial Mucosa
title_sort case of granulomatosis with polyangiitis (wegener’s granulomatosis) presenting with marked inflamed tracheobronchial mucosa
publisher Hindawi Limited
series Case Reports in Medicine
issn 1687-9627
1687-9635
publishDate 2013-01-01
description A 70-year-old man was admitted to our hospital because of weight loss and persistent dry cough. Chest radiograph and CT showed multiple infiltrates in the bilateral upper lobes and the remarkably thickened bronchial walls. Bronchoscopy revealed diffuse erythema and edema of the tracheobronchial mucosa without any ulcerous legions. Serum MPO-ANCA was positive (155 EU). Transbronchial biopsy was performed and revealed necrotic granulomas with multinucleated giant cells in the bronchial/bronchiolar and parenchymal lesions. Thus, we diagnosed it as a localized form of granulomatosis with polyangiitis (GPA, Wegener’s granulomatosis). After treatment with corticosteroid and cyclophosphamide, the bronchial findings were entirely resolved. We report here a rare case of GPA presenting with markedly inflamed tracheobronchial mucosa.
url http://dx.doi.org/10.1155/2013/208194
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