Striatal Neurodegeneration that Mimics Huntington’s Disease Modifies GABA-induced Currents

• Main Authors: Jorge Flores-Hernández, Jeanette A. Garzón-Vázquez, Gustavo Hernández-Carballo, Elizabeth Nieto-Mendoza, Evelyn A. Ruíz-Luna, Elizabeth Hernández-Echeagaray
• Format: Article
• Language: English
• Published: MDPI AG 2018-12-01
• Series: Brain Sciences
• Subjects: 3-NP; mitochondria; HD; gaboxadol; 2-AEMP; GABA_C.
• Online Access: https://www.mdpi.com/2076-3425/8/12/217

Huntington’s Disease (HD) is a degenerative disease which produces cognitive and motor disturbances. Treatment with GABAergic agonists improves the behavior and activity of mitochondrial complexes in rodents treated with 3-nitropropionic acid to mimic HD symptomatology. Apparently, GABA receptors activity may protect striatal medium spiny neurons (MSNs) from excitotoxic damage. This study evaluates whether mitochondrial inhibition with 3-NP that mimics the early stages of HD, modifies the kinetics and pharmacology of GABA receptors in patch clamp recorded dissociated MSNs cells. The results show that MSNs from mice treated with 3-NP exhibited differences in GABA-induced dose-response currents and pharmacological responses that suggests the presence of GABA_C receptors in MSNs. Furthermore, there was a reduction in the effect of the GABA_C antagonist that demonstrates a lessening of this GABA receptor subtype activity as a result of mitochondria inhibition.