Synthesis of Isoquinolinones via Regioselective Palladium-Catalyzed C–H Activation/Annulation

Synthesis of Isoquinolinones via Regioselective Palladium-Catalyzed C–H Activation/Annulation

The isoquinoline motif and its derivatives are of significant interest due to their important biological activities. The effective synthesis of substituted isoquinoline compounds has historically been a significant challenge. A new palladium-catalyzed C–H activation/annulation of N-methoxy benzamide...

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Bibliographic Details
Main Authors: Wenke Qi, Yimei Wu, Yongxu Han, Yi Li
Format: Article
Language:English
Published: MDPI AG 2017-10-01
Series:Catalysts
Subjects:
transition-metal catalyst
C–H activation
C–H functionalization
2,3-allenoic acid esters
hydroisoquinolinones
palladium-catalyzed annulation
Online Access:https://www.mdpi.com/2073-4344/7/11/320
Description
Summary:The isoquinoline motif and its derivatives are of significant interest due to their important biological activities. The effective synthesis of substituted isoquinoline compounds has historically been a significant challenge. A new palladium-catalyzed C–H activation/annulation of N-methoxy benzamides and 2,3-allenoic acid esters is described. For the first time, 2,3-allenoic acid esters are employed for the syntheses of 3,4-substituted hydroisoquinolones, the heteroannulation of allenes proceeded smoothly and afforded the products with good yields and excellent regioselectivity.
ISSN:2073-4344

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