Low TIM3 expression indicates poor prognosis of metastatic prostate cancer and acts as an independent predictor of castration resistant status
Abstract T cell immunoglobulin 3 (TIM3) is a cell surface star molecule expressed on T cells, and also marks dysfunctional CD8+ T cells in various kinds of cancers. However, there are few studies focusing on the expression of TIM3 in tumor cells. In our study, we recruited 139 patients with metastat...
Main Authors: | , , , , , , , , |
---|---|
Format: | Article |
Language: | English |
Published: |
Nature Publishing Group
2017-08-01
|
Series: | Scientific Reports |
Online Access: | https://doi.org/10.1038/s41598-017-09484-8 |
id |
doaj-39cac70173af47caa234244c5507cde9 |
---|---|
record_format |
Article |
spelling |
doaj-39cac70173af47caa234244c5507cde92020-12-08T02:38:07ZengNature Publishing GroupScientific Reports2045-23222017-08-01711910.1038/s41598-017-09484-8Low TIM3 expression indicates poor prognosis of metastatic prostate cancer and acts as an independent predictor of castration resistant statusJunlong Wu0Guowen Lin1Yao Zhu2Hailiang Zhang3Guohai Shi4Yijun Shen5Yiping Zhu6Bo Dai7Dingwei Ye8Department of Urology, Fudan University Shanghai Cancer CenterDepartment of Urology, Fudan University Shanghai Cancer CenterDepartment of Urology, Fudan University Shanghai Cancer CenterDepartment of Urology, Fudan University Shanghai Cancer CenterDepartment of Urology, Fudan University Shanghai Cancer CenterDepartment of Urology, Fudan University Shanghai Cancer CenterDepartment of Urology, Fudan University Shanghai Cancer CenterDepartment of Urology, Fudan University Shanghai Cancer CenterDepartment of Urology, Fudan University Shanghai Cancer CenterAbstract T cell immunoglobulin 3 (TIM3) is a cell surface star molecule expressed on T cells, and also marks dysfunctional CD8+ T cells in various kinds of cancers. However, there are few studies focusing on the expression of TIM3 in tumor cells. In our study, we recruited 139 patients with metastatic prostate cancer (mPCa) who received transurethral resection of the prostate (TURP) consecutively to examine whether TIM3 expression level is associated with overall survival (OS) in mPCa patients. Immunohistochemistry was performed to determine TIM3 expression in prostate cancer tissues and then patients were divided into two groups. In multivariate Cox analysis, we revealed that mPCa patients with negative TIM3 expression, younger age, no radiotherapy, higher Gleason score, higher cT stage and patients of mCRPC had a shorter OS. Therefore, a predictive nomogram was generated with identified independent prognostic factors to assess patients’ OS at 3 years. Multivariate logistic regression revealed that higher cT stage, higher Gleason score and low TIM3 expression were independent predictors of metastatic castration resistant prostate cancer (mCRPC). In conclusion, low expression level of TIM3 in prostate cancer tissues is an independent prognostic factor of poor prognosis for mPCa patients, and also an independent predictor of mCRPC.https://doi.org/10.1038/s41598-017-09484-8 |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Junlong Wu Guowen Lin Yao Zhu Hailiang Zhang Guohai Shi Yijun Shen Yiping Zhu Bo Dai Dingwei Ye |
spellingShingle |
Junlong Wu Guowen Lin Yao Zhu Hailiang Zhang Guohai Shi Yijun Shen Yiping Zhu Bo Dai Dingwei Ye Low TIM3 expression indicates poor prognosis of metastatic prostate cancer and acts as an independent predictor of castration resistant status Scientific Reports |
author_facet |
Junlong Wu Guowen Lin Yao Zhu Hailiang Zhang Guohai Shi Yijun Shen Yiping Zhu Bo Dai Dingwei Ye |
author_sort |
Junlong Wu |
title |
Low TIM3 expression indicates poor prognosis of metastatic prostate cancer and acts as an independent predictor of castration resistant status |
title_short |
Low TIM3 expression indicates poor prognosis of metastatic prostate cancer and acts as an independent predictor of castration resistant status |
title_full |
Low TIM3 expression indicates poor prognosis of metastatic prostate cancer and acts as an independent predictor of castration resistant status |
title_fullStr |
Low TIM3 expression indicates poor prognosis of metastatic prostate cancer and acts as an independent predictor of castration resistant status |
title_full_unstemmed |
Low TIM3 expression indicates poor prognosis of metastatic prostate cancer and acts as an independent predictor of castration resistant status |
title_sort |
low tim3 expression indicates poor prognosis of metastatic prostate cancer and acts as an independent predictor of castration resistant status |
publisher |
Nature Publishing Group |
series |
Scientific Reports |
issn |
2045-2322 |
publishDate |
2017-08-01 |
description |
Abstract T cell immunoglobulin 3 (TIM3) is a cell surface star molecule expressed on T cells, and also marks dysfunctional CD8+ T cells in various kinds of cancers. However, there are few studies focusing on the expression of TIM3 in tumor cells. In our study, we recruited 139 patients with metastatic prostate cancer (mPCa) who received transurethral resection of the prostate (TURP) consecutively to examine whether TIM3 expression level is associated with overall survival (OS) in mPCa patients. Immunohistochemistry was performed to determine TIM3 expression in prostate cancer tissues and then patients were divided into two groups. In multivariate Cox analysis, we revealed that mPCa patients with negative TIM3 expression, younger age, no radiotherapy, higher Gleason score, higher cT stage and patients of mCRPC had a shorter OS. Therefore, a predictive nomogram was generated with identified independent prognostic factors to assess patients’ OS at 3 years. Multivariate logistic regression revealed that higher cT stage, higher Gleason score and low TIM3 expression were independent predictors of metastatic castration resistant prostate cancer (mCRPC). In conclusion, low expression level of TIM3 in prostate cancer tissues is an independent prognostic factor of poor prognosis for mPCa patients, and also an independent predictor of mCRPC. |
url |
https://doi.org/10.1038/s41598-017-09484-8 |
work_keys_str_mv |
AT junlongwu lowtim3expressionindicatespoorprognosisofmetastaticprostatecancerandactsasanindependentpredictorofcastrationresistantstatus AT guowenlin lowtim3expressionindicatespoorprognosisofmetastaticprostatecancerandactsasanindependentpredictorofcastrationresistantstatus AT yaozhu lowtim3expressionindicatespoorprognosisofmetastaticprostatecancerandactsasanindependentpredictorofcastrationresistantstatus AT hailiangzhang lowtim3expressionindicatespoorprognosisofmetastaticprostatecancerandactsasanindependentpredictorofcastrationresistantstatus AT guohaishi lowtim3expressionindicatespoorprognosisofmetastaticprostatecancerandactsasanindependentpredictorofcastrationresistantstatus AT yijunshen lowtim3expressionindicatespoorprognosisofmetastaticprostatecancerandactsasanindependentpredictorofcastrationresistantstatus AT yipingzhu lowtim3expressionindicatespoorprognosisofmetastaticprostatecancerandactsasanindependentpredictorofcastrationresistantstatus AT bodai lowtim3expressionindicatespoorprognosisofmetastaticprostatecancerandactsasanindependentpredictorofcastrationresistantstatus AT dingweiye lowtim3expressionindicatespoorprognosisofmetastaticprostatecancerandactsasanindependentpredictorofcastrationresistantstatus |
_version_ |
1724393449282600960 |