Wharton’s Jelly-Derived Mesenchymal Stem Cells Reduce Fibrosis in a Mouse Model of Duchenne Muscular Dystrophy by Upregulating microRNA 499

Wharton’s Jelly-Derived Mesenchymal Stem Cells Reduce Fibrosis in a Mouse Model of Duchenne Muscular Dystrophy by Upregulating microRNA 499

The aim of this study was to evaluate the therapeutic effects and mechanisms of Wharton’s jelly-derived mesenchymal stem cells (WJ-MSCs) in an animal model of Duchenne muscular dystrophy (DMD). Mdx mice (3–5 months old) were administered five different doses of WJ-MSCs through their tail veins. A we...

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Bibliographic Details
Main Authors: Sang Eon Park, Jang Bin Jeong, Shin Ji Oh, Sun Jeong Kim, Hyeongseop Kim, Alee Choi, Suk-joo Choi, Soo-young Oh, Gyu Ha Ryu, Jeehun Lee, Hong Bae Jeon, Jong Wook Chang
Format: Article
Language:English
Published: MDPI AG 2021-08-01
Series:Biomedicines
Subjects:
Duchenne muscular dystrophy
microRNA-499-5p
skeletal muscle fibrosis
Wharton’s jelly-derived mesenchymal stem cell
Online Access:https://www.mdpi.com/2227-9059/9/9/1089

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https://www.mdpi.com/2227-9059/9/9/1089

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