Development, characterization, and hematopoietic differentiation of Griscelli syndrome type 2 induced pluripotent stem cells

Development, characterization, and hematopoietic differentiation of Griscelli syndrome type 2 induced pluripotent stem cells

Abstract Background Griscelli syndrome type 2 (GS-2) is a rare, autosomal recessive immune deficiency syndrome caused by a mutation in the RAB27A gene, which results in the absence of a protein involved in vesicle trafficking and consequent loss of function of in particular cytotoxic T and NK cells....

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Main Authors: Gülen Güney-Esken, Özgür Doğuş Erol, Burcu Pervin, Gülben Gürhan Sevinç, Tamer Önder, Elif Bilgiç, Petek Korkusuz, Ayşen Günel-Özcan, Duygu Uçkan-Çetinkaya, Fatima Aerts-Kaya
Format: Article
Language:English
Published: BMC 2021-05-01
Series:Stem Cell Research & Therapy
Subjects:
Griscelli syndrome type 2
Bone marrow
Mesenchymal stromal cells
Hematopoietic stem cells
Induced pluripotent stem cells
Online Access:https://doi.org/10.1186/s13287-021-02364-z

Internet

https://doi.org/10.1186/s13287-021-02364-z

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