Arbutin attenuates behavioral impairment and oxidative stress in an animal model of Parkinson's disease

• Main Authors: Masoumeh Dadgar, Mahdi Pouramir, Zohreh Dastan, Maryam Ghasemi-Kasman, Manouchehr Ashrafpour, Ali Akbar Moghadamnia, Soraya Khafri, Mohsen Pourghasem
• Format: Article
• Language: English
• Published: Mashhad University of Medical Sciences 2018-11-01
• Series: Avicenna Journal of Phytomedicine
• Subjects: Arbutin; Parkinson’s disease; Behavioral impairment; Oxidative stress; Nitrosative stress
• Online Access: http://ajp.mums.ac.ir/article_11510_460777637cffbd88ddaa93c0abda31a3.pdf

Objective: Arbutin has been shown to have antioxidant and free-radical scavenging properties. The aim of this study was to investigate the effects of arbutin administration on behavioral impairment, and oxidative and nitrosative stress in a 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine(MPTP)-induced animal model of Parkinson’s disease (PD). Materials and Methods: PD model was developed by 4 intraperitoneal (i.p.) injections of MPTP (20 mg/kg) with 2 h intervals in mice. Experimental groups received once daily injection of saline as vehicle (control group) or arbutin (50 mg/kg, i.p.) one week before MPTP injections and this protocol was continued seven days post lesion. Behavioral deficits were evaluated using locomotion test, hanging wire test and forepaw stride length. Parameters indicating the oxidation levels including lipid peroxidation marker (TBARS), nitrite, protein carbonyl levels and antioxidant activity including ferric reducing antioxidant power (FRAP) were assessed in serum and midbrain samples. Results: Treatment with arbutin improved motor functions in an MPTP-induced PD model compared to control group (p