Mechanistic insight into high-fat diet-induced metabolic inflammation in the arcuate nucleus of the hypothalamus

Mechanistic insight into high-fat diet-induced metabolic inflammation in the arcuate nucleus of the hypothalamus

A high-fat diet (HFD) is linked with cytokines production by non-neuronal cells within the hypothalamus, which mediates metabolic inflammation. These cytokines then activate different inflammatory mediators in the arcuate nucleus of the hypothalamus (ARC), a primary hypothalamic area accommodating p...

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Bibliographic Details
Main Authors: Rahim Ullah, Naveed Rauf, Ghulam Nabi, Shen Yi, Zhou Yu-Dong, Junfen Fu
Format: Article
Language:English
Published: Elsevier 2021-10-01
Series:Biomedicine & Pharmacotherapy
Subjects:
HFD
Metabolic inflammation
ARC
Altered POMC and AGRP functionality
Impaired metabolism
Online Access:http://www.sciencedirect.com/science/article/pii/S0753332221007952

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