Histamine combined with melphalan in isolated limb perfusion for the treatment of locally advanced soft tissue sarcomas: preclinical studies in rats Histamina combinada ao melfalano na perfusão de membro isolado para o tratamento de sarcomas de partes moles localmente avançado: estudos pré-clínicos em ratos

Histamine combined with melphalan in isolated limb perfusion for the treatment of locally advanced soft tissue sarcomas: preclinical studies in rats Histamina combinada ao melfalano na perfusão de membro isolado para o tratamento de sarcomas de partes moles localmente avançado: estudos pré-clínicos em ratos

PURPOSE: To evaluate the potential benefit of histamine combined with melphalan in the isolated limb perfusion (ILP) as an alternative to TNF-alfa and melphalan combination, for the treatment of irressectable soft tissue sarcomas of the limbs in Brown Norway (BN) rats. METHODS: 20 BN rats had small...

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Bibliographic Details
Main Authors: Flavia Brunstein, Ivan Dunshee de Abranches Oliveira Santos, Lydia Masako Ferreira, Sandra T. van Tiel, Alexander M. M. Eggermont, Timo L. M. Ten Hagen
Format: Article
Language:English
Published: Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia 2005-08-01
Series:Acta Cirurgica Brasileira
Subjects:
Sarcomas
Modelos experimentais
Tratamento regional
Histamina
Experimental models
Regional treatment
Histamine
Online Access:http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0102-86502005000400003

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