Effect of Iranian Propolis on Salivary Total Antioxidant Capacity in Gamma-irradiated Rats
Background and aims. The antioxidant and anti-inflammatory properties of propolis were studied. Since saliva contains antioxidants and radiotherapy of the head and neck mainly affects the saliva, salivary antioxidant defensive mechanism is compromised with oxidative stress produced by radiation th...
| Main Authors: | , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Tabriz University of Medical Sciences
2014-12-01
|
| Series: | Journal of Dental Research, Dental Clinics, Dental Prospects |
| Subjects: | |
| Online Access: | http://dentistry.tbzmed.ac.ir/joddd/index.php/joddd/article/view/659/421 |
| Summary: | Background and aims. The antioxidant and anti-inflammatory properties of propolis were studied. Since saliva contains
antioxidants and radiotherapy of the head and neck mainly affects the saliva, salivary antioxidant defensive mechanism is
compromised with oxidative stress produced by radiation therapy. Therefore, the aim of the present study was to investigate
the effect of propolis on salivary total antioxidant capacity in irradiated rats.
Materials and methods. The study was conducted on 28 rats, 7‒11 weeks of age (160±20 g), divided into four groups:
saline with no radiation (S), saline and radiation (SR), propolis with no radiation (P) [400 mg/kg IP], propolis and radiation
(PR) [400 mg/kg IP]. SP and PR were exposed to 15 Gy of gamma irradiation for 7 minutes and 39 seconds. The rats received
intraperitoneal injections each day for 10 days, and their tongues and lips were daily examined for mucositis; saliva
sample were also taken three times on days 0, 6, and 10.
Results. Mucositis incidence appeared to be delayed in the PR compared to the SR, and the severity was significantly
higher in the SR compared to the PR. No significant alterations were observed in salivary antioxidant levels during the experiment,
except the SR group in which a significant reduction was found.
Conclusion. Propolis might reduce and delay radiation-induced mucositis in animal models; it might be able to prevent the
reduction in salivary antioxidant levels in irradiated rats as well. |
|---|---|
| ISSN: | 2008-210X 2008-2118 |