Behavioral effects of congenital ventromedial prefrontal cortex malformation

• Main Authors: Boes Aaron D, Grafft Amanda, Joshi Charuta, Chuang Nathaniel A, Nopoulos Peg, Anderson Steven W
• Format: Article
• Language: English
• Published: BMC 2011-12-01
• Series: BMC Neurology
• Online Access: http://www.biomedcentral.com/1471-2377/11/151

<p>Abstract</p> <p>Background</p> <p>A detailed behavioral profile associated with focal congenital malformation of the ventromedial prefrontal cortex (vmPFC) has not been reported previously. Here we describe a 14 year-old boy, B.W., with neurological and psychiatric sequelae stemming from focal cortical malformation of the left vmPFC.</p> <p>Case Presentation</p> <p>B.W.'s behavior has been characterized through extensive review Patience of clinical and personal records along with behavioral and neuropsychological testing. A central feature of the behavioral profile is severe antisocial behavior. He is aggressive, manipulative, and callous; features consistent with psychopathy. Other problems include: egocentricity, impulsivity, hyperactivity, lack of empathy, lack of respect for authority, impaired moral judgment, an inability to plan ahead, and poor frustration tolerance.</p> <p>Conclusions</p> <p>The vmPFC has a profound contribution to the development of human prosocial behavior. B.W. demonstrates how a congenital lesion to this cortical region severely disrupts this process.</p>