Influence of smooth muscle contractility by inhibition of crac channels activity

Influence of smooth muscle contractility by inhibition of crac channels activity

The present in vitro study was focused on the differences in expression and activity of calcium release-activated calcium (CRAC) channels of human term-pregnant and non-pregnant myometrium. The expression of Orai1 protein, as a functional subunit of CRAC channel, was significantly higher than in non...

Full description

Bibliographic Details
Main Authors: Kocmálová M., Kazimierová I.
Format: Article
Language:English
Published: Sciendo 2017-09-01
Series:European Pharmaceutical Journal
Subjects:
oral n-acetylcysteine
inhaled n-acetylcysteine
mucus clearance
airway reactivity
Online Access:https://doi.org/10.1515/afpuc-2017-0001
id doaj-39b5902a2f6e4548bd18ca740bec78eb
record_format Article
spelling doaj-39b5902a2f6e4548bd18ca740bec78eb2021-09-06T19:39:44ZengSciendoEuropean Pharmaceutical Journal2453-67252017-09-01641101210.1515/afpuc-2017-0001Influence of smooth muscle contractility by inhibition of crac channels activityKocmálová M.0Kazimierová I.1Comenius University in Bratislava, Jessenius Faculty of Medicine in Martin, Biomedical Center Martin, Martin, Slovak RepublicComenius University in Bratislava, Jessenius Faculty of Medicine in Martin, Biomedical Center Martin, Martin, Slovak RepublicThe present in vitro study was focused on the differences in expression and activity of calcium release-activated calcium (CRAC) channels of human term-pregnant and non-pregnant myometrium. The expression of Orai1 protein, as a functional subunit of CRAC channel, was significantly higher than in non-pregnant myometrium. Lower Orai1 protein expression did not influence the amplitude of contractile response of term-pregnant myometrium, but higher Orai1 expression observed in non-pregnant myometrium was related to the different influence of CRAC blocker on contraction frequency.https://doi.org/10.1515/afpuc-2017-0001oral n-acetylcysteineinhaled n-acetylcysteinemucus clearanceairway reactivity
collection DOAJ
language English
format Article
sources DOAJ
author Kocmálová M.
Kazimierová I.
spellingShingle Kocmálová M.
Kazimierová I.
Influence of smooth muscle contractility by inhibition of crac channels activity
European Pharmaceutical Journal
oral n-acetylcysteine
inhaled n-acetylcysteine
mucus clearance
airway reactivity
author_facet Kocmálová M.
Kazimierová I.
author_sort Kocmálová M.
title Influence of smooth muscle contractility by inhibition of crac channels activity
title_short Influence of smooth muscle contractility by inhibition of crac channels activity
title_full Influence of smooth muscle contractility by inhibition of crac channels activity
title_fullStr Influence of smooth muscle contractility by inhibition of crac channels activity
title_full_unstemmed Influence of smooth muscle contractility by inhibition of crac channels activity
title_sort influence of smooth muscle contractility by inhibition of crac channels activity
publisher Sciendo
series European Pharmaceutical Journal
issn 2453-6725
publishDate 2017-09-01
description The present in vitro study was focused on the differences in expression and activity of calcium release-activated calcium (CRAC) channels of human term-pregnant and non-pregnant myometrium. The expression of Orai1 protein, as a functional subunit of CRAC channel, was significantly higher than in non-pregnant myometrium. Lower Orai1 protein expression did not influence the amplitude of contractile response of term-pregnant myometrium, but higher Orai1 expression observed in non-pregnant myometrium was related to the different influence of CRAC blocker on contraction frequency.
topic oral n-acetylcysteine
inhaled n-acetylcysteine
mucus clearance
airway reactivity
url https://doi.org/10.1515/afpuc-2017-0001
work_keys_str_mv AT kocmalovam influenceofsmoothmusclecontractilitybyinhibitionofcracchannelsactivity
AT kazimierovai influenceofsmoothmusclecontractilitybyinhibitionofcracchannelsactivity
_version_ 1717770155601166336

Similar Items