Systemic Administration of Polyelectrolyte Microcapsules: Where Do They Accumulate and When? In Vivo and Ex Vivo Study

Systemic Administration of Polyelectrolyte Microcapsules: Where Do They Accumulate and When? In Vivo and Ex Vivo Study

Multilayer capsules of 4 microns in size made of biodegradable polymers and iron oxide magnetite nanoparticles have been injected intravenously into rats. The time-dependent microcapsule distribution in organs was investigated in vivo by magnetic resonance imaging (MRI) and ex vivo by histological e...

Full description

Bibliographic Details
Main Authors: Nikita A. Navolokin, Sergei V. German, Alla B. Bucharskaya, Olga S. Godage, Viktor V. Zuev, Galina N. Maslyakova, Nikolaiy A. Pyataev, Pavel S. Zamyshliaev, Mikhail N. Zharkov, Georgy S. Terentyuk, Dmitry A. Gorin, Gleb B. Sukhorukov
Format: Article
Language:English
Published: MDPI AG 2018-10-01
Series:Nanomaterials
Subjects:
polymer microcapsules
magnetite nanoparticles
biodistribution
magnetic resonance imaging
electron spin resonance spectroscopy
histological examination
atomic absorption spectroscopy
intravenous injections
Online Access:http://www.mdpi.com/2079-4991/8/10/812

Internet

http://www.mdpi.com/2079-4991/8/10/812

Similar Items