The Quiescent Cellular State is Arf/p53-Dependent and Associated with H2AX Downregulation and Genome Stability

The Quiescent Cellular State is Arf/p53-Dependent and Associated with H2AX Downregulation and Genome Stability

Cancer is a disease associated with genomic instability and mutations. Excluding some tumors with specific chromosomal translocations, most cancers that develop at an advanced age are characterized by either chromosomal or microsatellite instability. However, it is still unclear how genomic instabil...

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Bibliographic Details
Main Authors: Mitsuko Masutani, Hirobumi Teraoka, Yuko Atsumi, Hirokazu Fukuda, Ken-ichi Yoshioka
Format: Article
Language:English
Published: MDPI AG 2012-05-01
Series:International Journal of Molecular Sciences
Subjects:
cancer
immortality
senescence
genome stability
tetraploidy
H2AX
Arf/p53
Online Access:http://www.mdpi.com/1422-0067/13/5/6492

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