Triphenylphosphonium Moiety Modulates Proteolytic Stability and Potentiates Neuroprotective Activity of Antioxidant Tetrapeptides in Vitro

Triphenylphosphonium Moiety Modulates Proteolytic Stability and Potentiates Neuroprotective Activity of Antioxidant Tetrapeptides in Vitro

Although delocalized lipophilic cations have been identified as effective cellular and mitochondrial carriers for a range of natural and synthetic drug molecules, little is known about their effects on pharmacological properties of peptides. The effect of triphenylphosphonium (TPP) cation on bioacti...

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Bibliographic Details
Main Authors: Rezeda A. Akhmadishina, Ruslan Garifullin, Natalia V. Petrova, Marat I. Kamalov, Timur I. Abdullin
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-02-01
Series:Frontiers in Pharmacology
Subjects:
aromatic-cationic oligopeptides
triphenylphosphonium compounds
antioxidant activity
Fenton reaction
neuronal cells
oxidative damage
Online Access:http://journal.frontiersin.org/article/10.3389/fphar.2018.00115/full

Internet

http://journal.frontiersin.org/article/10.3389/fphar.2018.00115/full

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